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Figure 2 | Journal of Immune Based Therapies and Vaccines

Figure 2

From: Kinetics and isotype profile of antibody responses in rhesus macaques induced following vaccination with HPV 6, 11, 16 and 18 L1-virus-like particles formulated with or without Merck aluminum adjuvant

Figure 2

HPV 6, 11, 16 and 18 L1 VLP-specific total IgG antibody titers. Sera from rhesus macaques immunized at week 0, 8 and 24 with 2 μg each of HPV 6, 11, 16 and 18L1-VLP formulated with Merck Aluminum Adjuvant (+MAA) (-◆-) or 2 μg each of HPV 6, 11, 16 and 18L1-VLPs alone (-MAA) (-◊ -) were collected at the indicated time points and tested for HPV 6, 11, 16 and 18 L1 VLP specific total IgG (-◆-, -◊ -) titers in a multiplexed detection assay. Responses are reported as the geometric means of end point dilution titers (n = 5 animals per group) for HPV 6, 11, 16 and 18 (2A, B, C, and D respectively). Arrows indicate vaccination boosts at weeks 8 and 24. The starting dilution for each sample was 1:10 and responses above an end point dilution of 10 were considered positive.

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Journal of Immune Based Therapies and Vaccines

ISSN: 1476-8518