| Bot/A Challenge* | Spore Challenge | SEB Challenge |
---|
 | Dose (LD50s) | Survival** | Dose (LD50s) | Survival | Dose (LD50s) | Survival |
---|
Control 1 | 57 | - | 507 | - | 33.5 | - |
Control 2 | 100 | - | 412 | - | 18.0 | - |
Vaccinated 1 | 50 | + | 257 | + | 26.4 | + |
Vaccinated 2 | 24 | + | 487 | + | 25.6 | + |
Vaccinated 3 | 99 | + | 439 | + | 15.8 | + |
Vaccinated 4 | 43 | + | 373 | + | 18.9 | + |
Vaccinated 5 | 82 | + | 275 | + | 19.6 | + |
Vaccinated 6 | 62 | + | 263 | + | 23.4 | + |
Mean+/-SD | 65+/-27 | Â | 377+/-101 | Â | 23+/-6 | Â |
- *All disease challenges occurred one month after the final vaccination.
- **Efficacy was evaluated using Fishers exact test comparing the treated group to the control group for each agent consisting of 2 experimental controls and 15 historical controls. Results indicated that the percentage of animals surviving in each treatment group (6/6 or 100%) was significantly higher than the percentage of animals surviving in each pooled (experimental plus historical) control group (0/17 or 0%), p < 0.0001.