Tumor–associated antigens identified by mRNA expression profiling as tumor rejection epitopes

Table 1 Potentially overexpressed p53^-/- SM7 thymoma proteins as analyzed by mRNA expression profiling including predicted, sequenced and assayed protein-derived H2^b binding peptides^a.

Protein name	Peptide sequence	Peptide name	KD nM^b
RAD50	RQIKNFHEL	RAD50 _391–399	45
RAD50	SQQRNFQLL	RAD50 _603–611	12
RAD50	SAEQNKNHI	RAD50 _1257–1265	13
RAD50	IISFFSPL	RAD50 _24–31	70
RAD50	QIISFFSPL	RA50 _23–31	280
RAD50	AIMKFHSM	RAD50 _1131–1139	36
Endonuclease*	YAYTFWTYM	Encl_261–269	80
RAD23	KALGFPESL	RAD23 _328–336	2950
PMS2	LGQFNLGFI	PMS2 _676–684	410
PMS2*	FGPQDIDEL	PMS2 _775–783	2
Cathepsin B*	FYNVDIDYL	CatB 47–55	155
Translin	VSEIFVEL	Translin _3–10	560
Protease-nexin 1*	WHEPFFIL	Pn1 _3–10	ND
Protease-nexin 1	VHSQFNSL	Pn1 _18–25	9500

^afor details see reference no. [8]^bdata are from ref. [13]. *Immunogenic peptides, see Figs 1,2.