Figure 4
From: Dendritic cells: In the forefront of immunopathogenesis and vaccine development – A review
Delivery of immunogenic antigen to DCs by probiotic microorganisms. DNA encoding sequences of DC-binding peptides and immunogenic subunit of any pathogen will be expressed in Gram positive bacteria including Lactobacillus. Lactobacillus will be orally administrated. These bacteria colonize the gut and express and release the immunogen in the intestine. DCs in the mucosal site will then capture the immunogen via DC-binding peptide motifs. They internalize the immunogen, process and present it to T cells inducing specific responses against released immunogen.