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Table 1 Human anti-anthrax PA83 antibody classification. The immunoglobulin sequence derived from the cDNA encoding the variable regions were used to search Vbase and the VH class, VH locus, DH and JH segments were assigned for the VH regions. Likewise VL class, VL locus and JL segments were assigned for the VL regions. Comparing the actual sequences and closest matched V family members the extent of somatic hyper mutation could be ascertained.

From: Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed

 

VH

V L

Designation

VH Class

VH Locus

# Mutations from germline

DH(RF)

JH

VL Class

VL Locus

# Mutations from Germline

JL

AVP-21D9

VH3

3–43

26

6–19(1)

JH4b

VKI

L12

14

JK1

AVP-1C6

VH3

3–73

8

6–13(1)

JH3b/a

VKI

L18

13

JK4

AVP-4H7

VH4

4–39

29

unknown

JH6b/a

VL3

3h

22

JL2/JL3a

AVP-22G12

VH3

3–11

20

unknown

JH5b

VL3

3r

9

JL2/JL3a