Table 2 Human anti-anthrax PA antibody kinetic binding data. The equilibrium dissociation constant (Kd) for recombinant form of the antibodies was determined by BiaCore analyses. The rate constants kon and koff were evaluated directly from the sensogram in the BiaCore analysis and the Kd was deduced.
Antibody | Dissociation Constant (KD) M | Association Rate (kon) M-1S-1 | Dissociation Rate (koff) S-1 |
|---|---|---|---|
AVP-21D9 | 8.21 × 10-11 | 1.80 × 105 | 1.48 × 10-5 |
AVP-1C6 | 7.11 × 10-10 | 1.85 × 105 | 1.31 × 10-4 |
AVP-4H7 | 1.41 × 10-10 | 1.74 × 105 | 2.45 × 10-5 |
AVP-22G12 | 5.12 × 10-10 | 1.01 × 105 | 5.17 × 10-5 |