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Table 1 Protease Profiles Expressed by Several DC Populations

From: Identification of proteases employed by dendritic cells in the processing of protein purified derivative (PPD)

Protease XS52 DC Splenic DC Bone Marrow DC BW5147 Thymoma Cells
Cathepsin B1 133 ± 392 123 ± 3.3 121 ± 3.3 1.5 ± 0.08
Cathepsin C 34 ± 7 16 ± 4 0.4 ± 0.1 <0.01
Cathepsin D/E 34 ± 6 30 ± 14 22 ± 2 1.6 ± 0.1
Cathepsin H 2.8 ± 0.8 3.5 ± 0.7 1 ± 0.2 0.9 ± 0.2
Cathepsin J 26 ± 0.3 0.7 ± 0.3 3.0 ± 0.1 0.2 ± 0.09
Cathepsin L 14 ± 0.6 26 ± 11 19 ± 0.6 0.6 ± 0.08
BLT esterase 25,000 ± 400 58,000 ± 4,000 21,300 ± 100 <100
Suc-FLF-SBz esterase 1,900,000 ± 61,000 310,000 ± 10,800 1,150,000 ± 10,200 12,000 ± 100
Suc-AAPFSBZ esterase 433,000 ± 2,900 134,000 ± 7,300 360,000 ± 6,100 3,400 ± 600
  1. 1Extracts prepared from the indicated cell types were examined for protease activities using a panel of standard substrates. 2Enzymatic activities are expressed as nmol/min/mg soluble protein. Data shown represent the mean ± SD from three independent preparations.