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Figure 1 | Journal of Immune Based Therapies and Vaccines

Figure 1

From: Antigenized antibodies expressing Vβ8.2 TCR peptides immunize against rat experimental allergic encephalomyelitis

Figure 1

Schematic representation of the two V regions antigenized with TCR sequences. In each case the H chain of the antigenized antibody is formed of a murine VH62 region in which the CDR3 has been engineered to express either 93ASSDSSNTE101 or 39DMGHGLRLIHYSYDVNSTEKG59 sequence between two Val-Pro (VP) doublets of the unique cloning site in the CDR3 loop of VH62. The complete H chain is the product of the fusion of the antigenized VH region with a human γ1C region. The light (L) chain (not shown) is the murine λ1 which is provided by the J558L host cell. (H chain not to scale).

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Journal of Immune Based Therapies and Vaccines

ISSN: 1476-8518