| | | |
Severity of Disease*
|
|---|
|
Group
|
No. Rats
|
Immunogen
|
Incidence
|
Max Score (mean ± SD)
|
Duration (mean ± SD)
|
Disease Index
|
|---|
|
I
|
6
|
γ1TCR-I
|
4/6
|
1.1 ± 0.9a
|
2.5 ± 2.2b
|
1.8
|
|
II
|
10
|
γ1TCR-II
|
8/10
|
1.6 ± 1.0c
|
3.8 ± 2.3d
|
4.9
|
|
III
|
10
|
γ1WT
|
10/10
|
2.2 ± 0.9
|
5.1 ± 1.0
|
11.3
|
|
IV
|
5
|
CFA
|
5/5
|
3.4 ± 0.9
|
6.6 ± 1.3
|
22.4
|
|
V
|
6
|
-
|
6/6
|
3.5 ± 0.5
|
7.2 ± 1.3
|
25.2
|
- * EAE was scored according to incidence, severity and duration. Disease index was calculated as follows: Mean Maximum Score × Mean Duration Disease × Incidence.
- Significance: (a) Group I vs Group III p = 0.04 and Group I vs Group V p = 0.0002; (b) Group I vs Group III p = 0.009 and Group I vs Group V p = 0.0001; (c) Group II vs Group III p = 0.16 and Group II vs Group V p = 0.0005; (d) Group II vs Group III p = 0.12 and Group II vs Group V p = 0.001.
