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Table 1 Vaccination against antigenized antibodies expressing TCR peptides protects from EAE

From: Antigenized antibodies expressing Vβ8.2 TCR peptides immunize against rat experimental allergic encephalomyelitis

   

Severity of Disease*

Group

No. Rats

Immunogen

Incidence

Max Score (mean ± SD)

Duration (mean ± SD)

Disease Index

I

6

γ1TCR-I

4/6

1.1 ± 0.9a

2.5 ± 2.2b

1.8

II

10

γ1TCR-II

8/10

1.6 ± 1.0c

3.8 ± 2.3d

4.9

III

10

γ1WT

10/10

2.2 ± 0.9

5.1 ± 1.0

11.3

IV

5

CFA

5/5

3.4 ± 0.9

6.6 ± 1.3

22.4

V

6

-

6/6

3.5 ± 0.5

7.2 ± 1.3

25.2

  1. * EAE was scored according to incidence, severity and duration. Disease index was calculated as follows: Mean Maximum Score × Mean Duration Disease × Incidence.
  2. Significance: (a) Group I vs Group III p = 0.04 and Group I vs Group V p = 0.0002; (b) Group I vs Group III p = 0.009 and Group I vs Group V p = 0.0001; (c) Group II vs Group III p = 0.16 and Group II vs Group V p = 0.0005; (d) Group II vs Group III p = 0.12 and Group II vs Group V p = 0.001.
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Journal of Immune Based Therapies and Vaccines

ISSN: 1476-8518