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Table 1 Vaccination against antigenized antibodies expressing TCR peptides protects from EAE

From: Antigenized antibodies expressing Vβ8.2 TCR peptides immunize against rat experimental allergic encephalomyelitis

    Severity of Disease*
Group No. Rats Immunogen Incidence Max Score (mean ± SD) Duration (mean ± SD) Disease Index
I 6 γ1TCR-I 4/6 1.1 ± 0.9a 2.5 ± 2.2b 1.8
II 10 γ1TCR-II 8/10 1.6 ± 1.0c 3.8 ± 2.3d 4.9
III 10 γ1WT 10/10 2.2 ± 0.9 5.1 ± 1.0 11.3
IV 5 CFA 5/5 3.4 ± 0.9 6.6 ± 1.3 22.4
V 6 - 6/6 3.5 ± 0.5 7.2 ± 1.3 25.2
  1. * EAE was scored according to incidence, severity and duration. Disease index was calculated as follows: Mean Maximum Score × Mean Duration Disease × Incidence.
  2. Significance: (a) Group I vs Group III p = 0.04 and Group I vs Group V p = 0.0002; (b) Group I vs Group III p = 0.009 and Group I vs Group V p = 0.0001; (c) Group II vs Group III p = 0.16 and Group II vs Group V p = 0.0005; (d) Group II vs Group III p = 0.12 and Group II vs Group V p = 0.001.