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Figure 1 | Journal of Immune Based Therapies and Vaccines

Figure 1

From: Kinetics and isotype profile of antibody responses in rhesus macaques induced following vaccination with HPV 6, 11, 16 and 18 L1-virus-like particles formulated with or without Merck aluminum adjuvant

Figure 1

HPV 6, 11, 16 and 18 type-specific antibody titers measured in the competitive Luminex Immunoassay (cLIA). Sera from rhesus macaques immunized with 2 μg each of HPV 6, 11, 16 and 18L1-VLPs formulated with Merck Aluminum Adjuvant (MAA) (-◆-) or 2 μg each of HPV 6, 11, 16 and 18L1-VLPs alone (-◊ -) were collected a t the indicated time points and tested for Abs to neutralizing epitopes on HPV 6, 11, 16 and 18 using the HPV cLIA. Responses are reported as GMTs in milli-Merck Units per milliliter (mMU/mL) (n = 5 animals per group) for HPV 6, 11, 16 and 18 (Fig 1A, 1B. 1C. and 1D respectively). Arrows indicate vaccination boosts at weeks 8 and 24. A one-tailed, un-paired t-Test analysis was conducted on log-transformed antibody titers obtained from the cLIA. Error bars represent the standard error of the titers within each group.

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Journal of Immune Based Therapies and Vaccines

ISSN: 1476-8518