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Figure 3 | Journal of Immune Based Therapies and Vaccines

Figure 3

From: Kinetics and isotype profile of antibody responses in rhesus macaques induced following vaccination with HPV 6, 11, 16 and 18 L1-virus-like particles formulated with or without Merck aluminum adjuvant

Figure 3

HPV L1-VLP specific IgM, IgA, IgG1 and IgG4 antibody titers. Sera from rhesus macaques immunized at week 0, 8 and 24 with 2 μg each of HPV 6, 11, 16 and 18 L1-VLPs formulated with Merck Aluminum Adjuvant (+MAA) (-◆-) or 2 μg each of HPV 6, 11, 16 and 18L1-VLPs alone (-MAA) (-◊ -) were collected at the indicated time points and tested for HPV L1 VLP specific (A) IgM, (B) IgA, (C) IgG1 and (D) IgG4 titers in a multiplexed detection assay. Responses are reported as GMTs (n = 5 monkeys per group) for HPV 16. Arrows indicate vaccination boosts at weeks 8 and 24. The starting dilution for each sample was 1:10 and responses above an end point dilution of 10 were considered above background. Graphs shown are for HPV 16 and are representative of HPV 6, 11, and 18.

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Journal of Immune Based Therapies and Vaccines

ISSN: 1476-8518