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Table 1 Comparison of intraperitoneal lethal doses (LD50) and body weights of control mice and those injected with phytol and PHIS-01.

From: Phytol-based novel adjuvants in vaccine formulation: 1. assessment of safety and efficacy during stimulation of humoral and cell-mediated immune responses

Test Adjuvants

Dose (μg)

Acute intoxication (% Survival in 24 h)

Mean body weight loss (%)

LD50 (mg/kg body weight)

   

Day 1

Day 3

Day 5

Day 7

 

PBS (Control)

250 (μl)

100

3.1

0

0

0

*ND

Phytol

40

100

13.86

19.41

24.75

15.92

>4

 

80

100

14.1

8.7

7.8

All dead

 
 

100

50

13.98

26.73

All dead

  

PHIS-01

40

100

3.8

10.16

9.08

8.9

>8

 

80

100

7.1

17.69

13.5

10.06

 
 

100

100

7.8

13.68

22.92

16.92

 
  1. * Not detected