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Figure 6 | Journal of Immune Based Therapies and Vaccines

Figure 6

From: Improved generation of anti-tumor immunity by antigen dose limitation

Figure 6

Expansion of CD8 T cell compartment following co-culture with DC loaded with low numbers of apoptotic CTCL cells. A. Autologous DC (106) were co-cultured with 1.0 × 106 and 0.25 × 106 apoptotic CTCL cells, followed by addition of freshly isolated autologous CTCL cells and CD8+ cells. Percentage of CD8+ T cells in co-culture increased significantly upon co-culture with autologous DC loaded with 0.25 × 106 apoptotic cells. B. The absolute number of CD8+ T cells increased upon co-culture with DC loaded with 0.25 × 106 apoptotic cells. Data analyzed using student's t test. Apoptotic = CD3-treated, Viable = CD4-treated, NS = Not significant.

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