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Figure 3 | Journal of Immune Based Therapies and Vaccines

Figure 3

From: CTLA-4 blockade during dendritic cell based booster vaccination influences dendritic cell survival and CTL expansion

Figure 3

Enhanced DC elimination during DC vaccination combined with CTLA-4 blockade. C57/Bl6 mice were immunized with peptide LCMV gp3333–41 loaded DCs with or without i.p. injection of anti-CTLA-4 mAb. After 7–10 days, an inoculum consisting of peptide LCMV 33–41 loaded CFSE labeled together with peptide unloaded CMTMR labeled DCs was injected subcutaneously into the distal forelimb of naïve mice (control), immunized mice or immunized mice cotreated with anti-CTLA-4 mAb. DCs were recovered from the draining lymph node for FACS analysis and determination of % surviving DCs. Results are shown as mean ± SD of nine mice from 3 separate experiments. (* p < 0.05; ***p < 0.0001)

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