Bach JF: Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev. 1994, 15 (4): 516-542.
Article
CAS
PubMed
Google Scholar
Castano L, Eisenbarth GS: Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu Rev Immunol. 1990, 8: 647-679. 10.1146/annurev.iy.08.040190.003243.
Article
CAS
PubMed
Google Scholar
Kolb H: Mouse models of insulin dependent diabetes: low-dose streptozocin-induced diabetes and nonobese diabetic (NOD) mice. Diabetes Metab Rev. 1987, 3 (3): 751-778. 10.1002/dmr.5610030308.
Article
CAS
PubMed
Google Scholar
Like AA, Rossini AA: Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science. 1976, 193 (4251): 415-417. 10.1126/science.180605.
Article
CAS
PubMed
Google Scholar
Haskins K, Wegmann D: Diabetogenic T-cell clones. Diabetes. 1996, 45 (10): 1299-1305. 10.2337/diabetes.45.10.1299.
Article
CAS
PubMed
Google Scholar
Wang B, Gonzalez A, Benoist C, Mathis D: The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus. Eur J Immunol. 1996, 26 (8): 1762-1769. 10.1002/eji.1830260815.
Article
CAS
PubMed
Google Scholar
Gottlieb PA, Eisenbarth GS: Diagnosis and treatment of pre-insulin dependent diabetes. Annu Rev Med. 1998, 49: 391-405. 10.1146/annurev.med.49.1.391.
Article
CAS
PubMed
Google Scholar
Birk OS, Elias D, Weiss AS, Rosen A, Zee van-der R, Walker MD, Cohen IR: NOD mouse diabetes: the ubiquitous mouse hsp60 is a beta-cell target antigen of autoimmune T cells. J Autoimmun. 1996, 9 (2): 159-166. 10.1006/jaut.1996.0019.
Article
CAS
PubMed
Google Scholar
Elias D, Reshef T, Birk OS, Zee van der R, Walker MD, Cohen IR: Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci USA. 1991, 88 (8): 3088-3091. 10.1073/pnas.88.8.3088.
Article
PubMed Central
CAS
PubMed
Google Scholar
Elias D, Bone AJ, Baird JD, Cooke A, Cohen IR: Insulin-mimicking anti-idiotypic antibodies in development of spontaneous autoimmune diabetes in BB/E rats. Diabetes. 1990, 39 (12): 1467-1471. 10.2337/diabetes.39.12.1467.
Article
CAS
PubMed
Google Scholar
Daniel D, Wegmann DR: Intranasal administration of insulin peptide B: 9-23 protects NOD mice from diabetes. Ann N Y Acad Sci. 1996, 778: 371-372. 10.1111/j.1749-6632.1996.tb21146.x.
Article
CAS
PubMed
Google Scholar
Harrison LC, Dempsey-Collier M, Kramer DR, Takahashi K: Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent diabetes. J Exp Med. 1996, 184 (6): 2167-2174. 10.1084/jem.184.6.2167.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kaufman DL, Clare-Salzler M, Tian J, Forsthuber T, Ting GS, Robinson P, Atkinson MA, Sercarz EE, Tobin AJ, Lehmann PV: Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature. 1993, 366 (6450): 69-72. 10.1038/366069a0.
Article
CAS
PubMed
Google Scholar
Maron R, Melican NS, Weiner HL: Regulatory Th2-type T cell lines against insulin and GAD peptides derived from orally- and nasally-treated NOD mice suppress diabetes. J Autoimmun. 1999, 12 (4): 251-258. 10.1006/jaut.1999.0278.
Article
CAS
PubMed
Google Scholar
Muir A, Peck A, Clare-Salzler M, Song YH, Cornelius J, Luchetta R, Krischer J, Maclaren N: Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription. J Clin Invest. 1995, 95 (2): 628-634. 10.1172/JCI117707.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tisch R, Yang XD, Singer SM, Liblau RS, Fugger L, McDevitt HO: Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature. 1993, 366 (6450): 72-75. 10.1038/366072a0.
Article
CAS
PubMed
Google Scholar
O'Garra A: Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity. 1998, 8 (3): 275-283. 10.1016/S1074-7613(00)80533-6.
Article
PubMed
Google Scholar
Shevach EM: Regulatory T cells in autoimmmunity*. Annu Rev Immunol. 2000, 18: 423-449. 10.1146/annurev.immunol.18.1.423.
Article
CAS
PubMed
Google Scholar
Donnelly JJ, Ulmer JB, Shiver JW, Liu MA: DNA vaccines. Annu Rev Immunol. 1997, 15: 617-648. 10.1146/annurev.immunol.15.1.617.
Article
CAS
PubMed
Google Scholar
Silva CB, VLD Coelho Castelo AAM, Lima KM, Rodrigues JM, (ed): Vacinas Gênicas, Capítulo 23. 2004
Lobell A, Weissert R, Storch MK, Svanholm C, de Graaf KL, Lassmann H, Andersson R, Olsson T, Wigzell H: Vaccination with DNA encoding an immunodominant myelin basic protein peptide targeted to Fc of immunoglobulin G suppresses experimental autoimmune encephalomyelitis. J Exp Med. 1998, 187 (9): 1543-1548. 10.1084/jem.187.9.1543.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ruiz PJ, Garren H, Ruiz IU, Hirschberg DL, Nguyen LV, Karpuj MV, Cooper MT, Mitchell DJ, Fathman CG, Steinman L: Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: modulation of T cell costimulation. J Immunol. 1999, 162 (6): 3336-3341.
CAS
PubMed
Google Scholar
Youssef S, Maor G, Wildbaum G, Grabie N, Gour-Lavie A, Karin N: C-C chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis. J Clin Invest. 2000, 106 (3): 361-371. 10.1172/JCI9109.
Article
PubMed Central
CAS
PubMed
Google Scholar
Quintana FJ, Rotem A, Carmi P, Cohen IR: Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: modulation of spontaneous 60-kDa heat shock protein autoimmunity. J Immunol. 2000, 165 (11): 6148-6155.
Article
CAS
PubMed
Google Scholar
Bonato VL, Goncalves ED, Soares EG, Santos Junior RR, Sartori A, Coelho-Castelo AA, Silva CL: Immune regulatory effect of pHSP65 DNA therapy in pulmonary tuberculosis: activation of CD8+ cells, interferon-gamma recovery and reduction of lung injury. Immunology. 2004, 113 (1): 130-138. 10.1111/j.1365-2567.2004.01931.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bonato VL, Lima VM, Tascon RE, Lowrie DB, Silva CL: Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosis-infected mice. Infect Immun. 1998, 66 (1): 169-175.
PubMed Central
CAS
PubMed
Google Scholar
Lowrie DB, Tascon RE, Bonato VL, Lima VM, Faccioli LH, Stavropoulos E, Colston MJ, Hewinson RG, Moelling K, Silva CL: Therapy of tuberculosis in mice by DNA vaccination. Nature. 1999, 400 (6741): 269-271. 10.1038/22326.
Article
CAS
PubMed
Google Scholar
Silva CL, Bonato VL, Lima VM, Faccioli LH, Leao SC: Characterization of the memory/activated T cells that mediate the long-lived host response against tuberculosis after bacillus Calmette-Guerin or DNA vaccination. Immunology. 1999, 97 (4): 573-581. 10.1046/j.1365-2567.1999.00840.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Santos-Junior RR, Sartori A, De Franco M, Filho OG, Coelho-Castelo AA, Bonato VL, Cabrera WH, Ibanez OM, Silva CL: Immunomodulation and protection induced by DNA-hsp65 vaccination in an animal model of arthritis. Hum Gene Ther. 2005, 16 (11): 1338-1345. 10.1089/hum.2005.16.1338.
Article
CAS
PubMed
Google Scholar
Santos-Junior RR, Sartori A, Bonato VLD, Coelho-Castelo AAM, Vilella C, Zollner R, Silva CL: Immune Modulation Induced by Tuberculosis DNA vaccine Protects NOD Mice from Diabetes Progerssion. Clinical Experimental Immunology. 2007, 149 (00): 570-578.
Article
PubMed
Google Scholar
Lowrie DB, Silva CL, Colston MJ, Ragno S, Tascon RE: Protection against tuberculosis by a plasmid DNA vaccine. Vaccine. 1997, 15 (8): 834-838. 10.1016/S0264-410X(97)00073-X.
Article
CAS
PubMed
Google Scholar
Elias D, Prigozin H, Polak N, Rapoport M, Lohse AW, Cohen IR: Autoimmune diabetes induced by the beta-cell toxin STZ. Immunity to the 60-kDa heat shock protein and to insulin. Diabetes. 1994, 43 (8): 992-998. 10.2337/diabetes.43.8.992.
Article
CAS
PubMed
Google Scholar
Bonato VL, Goncalves ED, Santos RR, Silva CL: Genetic aspects and microenvironment affect expression of CD18 and VLA-4 in experimental tuberculosis. Scand J Immunol. 2002, 56 (2): 185-194. 10.1046/j.1365-3083.2002.01121.x.
Article
CAS
PubMed
Google Scholar
Abramoff MD, Magelhaes PJ, Ram SJ: Image Processing with ImageJ. Biophotonics International. 2004, 11 (7): 36-42.
Google Scholar
Zhang ZL, Shen SX, Lin B, Yu LY, Zhu LH, Wang WP, Luo FH, Guo LH: Intramuscular injection of interleukin-10 plasmid DNA prevented autoimmune diabetes in mice. Acta Pharmacol Sin. 2003, 24 (8): 751-756.
CAS
PubMed
Google Scholar
Maron R, Sukhova G, Faria AM, Hoffmann E, Mach F, Libby P, Weiner HL: Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation. 2002, 106 (13): 1708-1715. 10.1161/01.CIR.0000029750.99462.30.
Article
CAS
PubMed
Google Scholar
Zanin-Zhorov A, Cahalon L, Tal G, Margalit R, Lider O, Cohen IR: Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling. J Clin Invest. 2006, 116 (7): 2022-2032. 10.1172/JCI28423.
Article
PubMed Central
CAS
PubMed
Google Scholar
Green EA, Choi Y, Flavell RA: Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity. 2002, 16 (2): 183-191. 10.1016/S1074-7613(02)00279-0.
Article
CAS
PubMed
Google Scholar
Bresson D, Togher L, Rodrigo E, Chen Y, Bluestone JA, Herold KC, von Herrath M: Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Invest. 2006, 116 (5): 1371-1381. 10.1172/JCI27191.
Article
PubMed Central
CAS
PubMed
Google Scholar
Silva CL, Bonato VL, dos Santos-Junior RR, Zarate-Blades CR, Sartori A: Recent advances in DNA vaccines for autoimmune diseases. Expert Rev Vaccines. 2009, 8 (2): 239-252. 10.1586/14760584.8.2.239.
Article
CAS
PubMed
Google Scholar
van Eden W, Zee van der R, Prakken B: Heat-shock proteins induce T-cell regulation of chronic inflammation. Nat Rev Immunol. 2005, 5 (4): 318-330. 10.1038/nri1593.
Article
CAS
PubMed
Google Scholar
Kodama S, Kuhtreiber W, Fujimura S, Dale EA, Faustman DL: Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science. 2003, 302 (5648): 1223-1227. 10.1126/science.1088949.
Article
CAS
PubMed
Google Scholar
Nishio J, Gaglia JL, Turvey SE, Campbell C, Benoist C, Mathis D: Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Science. 2006, 311 (5768): 1775-1778. 10.1126/science.1124004.
Article
CAS
PubMed
Google Scholar