CpG ODN 10103 differently protects mice from aerosolized B. pseudomallei 1026b and F. tularensis Schu S4 challenges. Groups of 8-10 C57BL6/J mice were given saline (bold solid lines) or 150 μg CpG ODN 10103 via intranasal (bold dashed lines) or intraperitoneal (thin solid lines) injection 48 h before or 1 h after being challenged with aerosolize B. pseudomallei 1026b or F. tularensis Schu S4 and observed for 14-28 days. The calculated inhaled bacterial doses are given above each graph. Intraperitoneal and 1 h post-challenge therapies were only administered during the low-dose challenges. Survival curves were compared using log-rank (Mantel-Cox) tests.