Figure 1From: CpG oligodeoxyribonucleotides protect mice from Burkholderia pseudomallei but not Francisella tularensis Schu S4 aerosolsCpG ODN 10103 differently protects mice from aerosolized B. pseudomallei 1026b and F. tularensis Schu S4 challenges. Groups of 8-10 C57BL6/J mice were given saline (bold solid lines) or 150 μg CpG ODN 10103 via intranasal (bold dashed lines) or intraperitoneal (thin solid lines) injection 48 h before or 1 h after being challenged with aerosolize B. pseudomallei 1026b or F. tularensis Schu S4 and observed for 14-28 days. The calculated inhaled bacterial doses are given above each graph. Intraperitoneal and 1 h post-challenge therapies were only administered during the low-dose challenges. Survival curves were compared using log-rank (Mantel-Cox) tests.Back to article page