Figure 5
From: HIV-1 sub-type C chimaeric VLPs boost cellular immune responses in mice
Use of a mixture of GagRT and GagTN VLPs as vaccine boosts. BALB/c mice were vaccinated with the DNA vaccine pVRCgrttnC on day 0 and day 28 (DNA+DNA group) or primed on day 0 with the DNA vaccine and boosted on day 28 with a mix of GagRT and GagTN (DNA+VLPmix group). For all mouse groups spleens were harvested on day 40 and splenocytes used in IFN-γ ELISPOT and IL-2 ELISPOT assays with the indicated Gag and RT CD8 and CD4 peptides. Data represent results from one of three representative experiments.