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Table 1 Analysis of cytokines and chemokines secreted by mature DCs

From: Ex vivo development, expansion and in vivoanalysis of a novel lineage of dendritic cells from hematopoietic stem cells

Cytokines/Chemokines IL-4 DCs (pg/ml) IL-15 DCs (pg/ml) DCPs (pg/ml)
IL-1α 135 (32) 332 (1,228) ↑ 1,202 (239) ↑
IL-1β 338 (92) 601 (2,696) ↑ 8,582 (2,440) ↑↑
IL-2 6 (5) 7 (7) 6 (4)
IL-4 3 (3) 2 (4) 2 (1) ↓
IL-5 2 (1) 4 (7) ↑ 9 (6) ↑
IL-6 652 (53) 1,664 (8,036) ↑ 43,607 (4,605) ↑↑
IL-8 154,440 (55,237) 155,499 (297,615) ↑ 303,222 (286,234) ↑
IL-10 68 (53) 7 (114) 110 (162) ↑
IL-12p70 6 (3) 16 (25) ↑ 8 (6) ↑
IL-13 6 (5) 170 (148) ↑↑ 10 (11) ↑
IL-15 25 (23) 2,359 (248) ↑↑ 87 (81) ↑
IL-17 8 (4) 12 (13) ↑ 5 (6)
IL-23 17 (30) 79 (90) ↑ 215 (36) ↑
IFN-γ < 1 ( < 1) 2,331 (1,905) ↑↑ < 1 (1)
TNFα 149 (72) 1,439 (3,152) ↑↑ 226 (70)
TNFβ < 1 (2) 87 (67) ↑ 3 (6) ↑
Eotaxin 2 (3) 3 (3) 4 (2)
GRO-α 8,394 (2,158) 2,142 (15,744) 131,310 (19,241) ↑↑
I-309 1,989 (533) 15,086 (28,758) ↑ 18,141 (42,805) ↑↑
MCP-1 342 (571) 547 (4,971) ↑ 184,457 (127,001) ↑↑
MCP-2 11 (9) 339 (2,512) ↑↑ 2,381 (46) ↑
RANTES 1,588 (179) 2,552 (1,875) ↑ 1,666 (3,085) ↑
TARC 469,352 (337,109) 1,783 (1,636) ↓ 20,739 (14,855) ↓
  1. Results are averages of triplicate analyses of cytokines and chemokines (pg/ml/106 cells/24 hr) secreted by mature DCs of two donors (the 2nd donor shown in parenthesis) using multiplex ELISA arrays. Up-(↑) and down-regulations (↓) are depicted by arrows, and double arrows indicate a difference more than ten-fold from the IL-4 DCs.
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