|
Cytokines/Chemokines
|
IL-4 DCs (pg/ml)
|
IL-15 DCs (pg/ml)
|
DCPs (pg/ml)
|
|---|
|
IL-1α
|
135 (32)
|
332 (1,228) ↑
|
1,202 (239) ↑
|
|
IL-1β
|
338 (92)
|
601 (2,696) ↑
|
8,582 (2,440) ↑↑
|
|
IL-2
|
6 (5)
|
7 (7)
|
6 (4)
|
|
IL-4
|
3 (3)
|
2 (4)
|
2 (1) ↓
|
|
IL-5
|
2 (1)
|
4 (7) ↑
|
9 (6) ↑
|
|
IL-6
|
652 (53)
|
1,664 (8,036) ↑
|
43,607 (4,605) ↑↑
|
|
IL-8
|
154,440 (55,237)
|
155,499 (297,615) ↑
|
303,222 (286,234) ↑
|
|
IL-10
|
68 (53)
|
7 (114)
|
110 (162) ↑
|
|
IL-12p70
|
6 (3)
|
16 (25) ↑
|
8 (6) ↑
|
|
IL-13
|
6 (5)
|
170 (148) ↑↑
|
10 (11) ↑
|
|
IL-15
|
25 (23)
|
2,359 (248) ↑↑
|
87 (81) ↑
|
|
IL-17
|
8 (4)
|
12 (13) ↑
|
5 (6)
|
|
IL-23
|
17 (30)
|
79 (90) ↑
|
215 (36) ↑
|
|
IFN-γ
|
< 1 ( < 1)
|
2,331 (1,905) ↑↑
|
< 1 (1)
|
|
TNFα
|
149 (72)
|
1,439 (3,152) ↑↑
|
226 (70)
|
|
TNFβ
|
< 1 (2)
|
87 (67) ↑
|
3 (6) ↑
|
|
Eotaxin
|
2 (3)
|
3 (3)
|
4 (2)
|
|
GRO-α
|
8,394 (2,158)
|
2,142 (15,744)
|
131,310 (19,241) ↑↑
|
|
I-309
|
1,989 (533)
|
15,086 (28,758) ↑
|
18,141 (42,805) ↑↑
|
|
MCP-1
|
342 (571)
|
547 (4,971) ↑
|
184,457 (127,001) ↑↑
|
|
MCP-2
|
11 (9)
|
339 (2,512) ↑↑
|
2,381 (46) ↑
|
|
RANTES
|
1,588 (179)
|
2,552 (1,875) ↑
|
1,666 (3,085) ↑
|
|
TARC
|
469,352 (337,109)
|
1,783 (1,636) ↓
|
20,739 (14,855) ↓
|
- Results are averages of triplicate analyses of cytokines and chemokines (pg/ml/106 cells/24 hr) secreted by mature DCs of two donors (the 2nd donor shown in parenthesis) using multiplex ELISA arrays. Up-(↑) and down-regulations (↓) are depicted by arrows, and double arrows indicate a difference more than ten-fold from the IL-4 DCs.
