Prophylactic administration of HuMAb-154 protected mice exposed to lethal doses of SEB challenge. A) Kaplan-Meier survival chart demonstrates dose escalation of SEB in LPS prime model to find the minimal dose of SEB to reach 100% mortality (n = 5). B) Effect of HuMAb-154 at a fixed dose (500 μg) in the protection of LPS primed mice from an escalating SEB challenge. Each HuMAb-154 group contained an n of 10 while the untreated contained an n of 5. Survival of each SEB challenge group that was administered HuMAb-154 was significant (P < 0.015) as compared to the 5 μg SEB challenge group that was not administered HuMAb-154.