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Figure 3 | Journal of Immune Based Therapies and Vaccines

Figure 3

From: Immunotherapeutic role of Ag85B as an adjunct to antituberculous chemotherapy

Figure 3

Effect of immunotherapy on persisters in terms of Log 10 CFUs of Mtb at two weeks post treatment in the lungs and spleen of Mtb infected animals. Two weeks post challenge with Mtb, mice were treated with ATD for 4 weeks and then 4 doses of rAg85B weekly. Two weeks post treatment lungs and spleen from M. tuberculosis H37Rv infected animals were isolated and cultured on Middlebrook 7H11 agar plates. Results are expressed as mean log10 CFUs ± standard deviation of 5 animals per group tested individually. Statistical analysis of the results was carried out by Student's t test. ***p< 0.001, compared to animals that were left untreated during the treatment period of eight weeks. #p< 0.05, compared to animals receiving ATD for four weeks. (ATD: Antituberculous Drugs; IT: Immunotherapy; O/W: Once Weekly)

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