Immunotherapeutic role of Ag85B as an adjunct to antituberculous chemotherapy

Table 1 Bacterial load in terms of CFU in lung and spleen of infected animals after immunotherapy and short-term chemotherapy

Groups	No. of CFU(× 10⁵) in
	Lung	± 95% CI	P value	Spleen	± 95% CI	P value
Basal	2.66 ± 0.254	0.22 (5.20-5.64)		1.22 ± 0.616	0.54 (4.54-5.62)
Untreated	83.72 ± 0.527	0.46 (6.46-7.38)		12.5 ± 0.707	0.62 (5.47-6.71)
ATD dialy	0.196 ± 0.814	0.71 (3.58-5.00)	0.0003 *	0.080 ± 0.509	0.45 (3.45-4.35)	0.0005 *
IT	0.507 ± 0.639	0.56 (4.14-5.26)	0.0003 *	0.061 ± 0.47	0.41 (3.37-4.19)	0.0003 *
ATD dialy+ IT(o/w)	0.086 ± 0.523	0.46 (3.47-4.39)	0.0001 *	0.029 ± 0.448	0.39 (3.07-3.85)	0.0001 *
ATD(o/w) +IT (o/w)	0.435 ± 0.978	0.86 (3.77-5.49)	0.0017 *	0.114 ± 0.667	0.58 (3.47-4.63)	0.0016 *
Untreated (2 months)	147 ± 0.551	0.48 (6.68-7.64)		15.6 ± 0.028	0.02 (6.17-6.21)
ATD dialy 1 month + 1 month adjuvant immunized	1.29 ± 0.315	0.28 (4.83-5.39)		2.70 ± 0.99	0.87 (4.56-6.3)
ATD dialy (1 month) + IT next month (o/w)	0.31 ± 0.319	0.28 (4.21-4.77)	0.0001 $ 0.014 #	0.088 ± 0.44	0.39 (3.55-4.33)	0.0001 $ 0.015 #

* With respect to Untreated
$ With respect to group Untreated (2 months)
# With respect to group ATD daily 1 month + 1 month adjuvant immunized
CFU: colony Forming Units; ATD: Anti Tuberculous Drugs; IT: Immunotherapy; o/w: Once Weekly;