Paratuberculosis control: a review with a focus on vaccination

Bastida, Felix; Juste, Ramon A

doi:10.1186/1476-8518-9-8

Journal of Immune Based Therapies and Vaccines

Table 3 Production effects (Paratuberculosis clinical cases or mortality rates).

From: Paratuberculosis control: a review with a focus on vaccination

Vaccine				Country and reference	Year	Number of animals	Age at vaccination	Reduction (%)	Type of trial
Name/Laboratory	Type	Strain/Antigen	Adjuvant
				Cattle
NCV	Live	6 strains	Oil	U.S.A. [65]	1935	20	1 m	100,00	E, MC, CC
Weybridge	Live	316F	P/O/P	U.K. [66]	1959	63401	1 m	93.45	F, IF, CC
Weybridge	Live	316F	P/O/P	U.K. [67]	1964	2440	1 m	98.36	F, IF, CC
Weybridge	Live	316F	P/O/P	U.K. [68]	1965	84	1 w	46.67	E, MC, CC
Weybridge	Live	316F	P/O/P	U.K. [69]	1982	150000	1 m	99.06	F, IF, CC
Fromm	Killed	M.a.a strain 18	Oil	U.S.A. [70]	1983	48	1 m	35.29	F, MC, CC
-	Live	316F	P/O/P	France [61]	1988	902	1 m	87.34	F, IF, CC
-	Live	316F	P/O/P	France [61]	1988	1037	1 m	97.22	F, IF, CC
Lelystad	Killed	-	Oil	Netherlands [59]	1988	851	1-24 m	87.05	F, IF, CC
Lelystad	Killed	-	Oil	Netherlands [71]	1992	61050	1 m	91.82	F, MC, CC
NCV	Killed	-	Oil	Netherlands [72]	1994	337	1 m	79.01	F, IF, CC
NCV	Killed	-	Oil	Netherlands [37]	1996	573	1 m	68.14	F, CC
Average								96.02 ± 0.01
Sheep
NCV	Live	316F	Oil Paraffin	Greece [73]	1988	1448	1 m	76.14	F, MC, TM
NCV	Live	316F	Oil Paraffin	Greece [73]	1988	5526	Adults	28.74	F, MC, TM
Lio-Johne	Live	316F	Oil	Spain [74]	1993	1201	Adults	78.29	F, MC, CC
Lio-Johne	Live	316F	Oil	Spain [75]	1995	570	1 m	52.55	F, MC, TM
Weybridge	Live	316F	P/O/P	U.K. [76]	1993	830	Adults	89.86	F, IF, CC
Neoparasec & NCV	Live & Killed	316F -	Oil Oil	Spain [77]	1995	857	Adults	54.55	F, IF, CC
Neoparasec	Live	316F	Oil	New Zealand [78]	2000	28	1-1.5 m	71.43	E, MC, CC
Gudair	Killed	316F	Oil	Australia [79]	2003	8000	3, 8 m, 2 y	87.50	F, IF, mort rate
Gudair	Killed	316F	Oil	Australia [80]	2004	1200	1-4 m	90.00	F,MC, mort reduction
Gudair	Killed	316F	Oil	Australia [34]	2006	400	1-3 m	91.25	F, MC, TM
Gudair	Killed	316F	Oil	New Zealand [81]	2009	65	4 m	78.57	E, MC, CA
NCV	Killed	316F	Lipid-K formulation	New Zealand [81]	2009	65	4 m	57.14	E, MC, CA
NCV	Live	316F	Lipid-K formulation	New Zealand [81]	2009	65	4 m	14.29	E, MC, CA
NCV	Live	316F	Lipid-K formulation	New Zealand [81]	2009	65	4 m	35.71	E, MC, CA
Average								67.57% ± 0.35
Goats
NCV	Live	316F	Oil Paraffin	Greece [73]	1988	2178	1 m	82.78	F, MC, TM
NCV	Live	316F	Oil Paraffin	Greece [73]	1988	7773	Adults	34.52	F, MC, TM
Average								45.08 ± 0.39

NCV: non-commercial vaccine; Weybridge: Central Veterinary Laboratory, Weybridge, UK; Fromm: Fromm Laboratories, Grafton, Wisconsin USA; Lelystad: Central Veterinary Institute, Lelystad, The Netherlands; Lio-Johne, Ovejero, Spain; Neoparasec: Neoparasec^®, Merial; Gudair: Gudair^®, CZ Veterinaria/Pfizer; P/O/P Paraffin, Olive Oil, Pumice Stone Powder; y: year(s); m: month(s); w: week(s); d: day(s); F: Field trial; E: Experimental infection; MC: Comparison to matched controls; IF: Comparison of initial versus final prevalence; TM: Total mortality; CC: clinical cases; NVH: Comparison to non-vaccinating herds.

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