Skip to main content

Table 3 Production effects (Paratuberculosis clinical cases or mortality rates).

From: Paratuberculosis control: a review with a focus on vaccination

Vaccine Country and reference Year Number of animals Age at vaccination Reduction
(%)
Type of trial
Name/Laboratory Type Strain/Antigen Adjuvant       
     Cattle      
NCV Live 6 strains Oil U.S.A. [65] 1935 20 1 m 100,00 E, MC, CC
Weybridge Live 316F P/O/P U.K. [66] 1959 63401 1 m 93.45 F, IF, CC
Weybridge Live 316F P/O/P U.K. [67] 1964 2440 1 m 98.36 F, IF, CC
Weybridge Live 316F P/O/P U.K. [68] 1965 84 1 w 46.67 E, MC, CC
Weybridge Live 316F P/O/P U.K. [69] 1982 150000 1 m 99.06 F, IF, CC
Fromm Killed M.a.a strain 18 Oil U.S.A. [70] 1983 48 1 m 35.29 F, MC, CC
- Live 316F P/O/P France [61] 1988 902 1 m 87.34 F, IF, CC
- Live 316F P/O/P France [61] 1988 1037 1 m 97.22 F, IF, CC
Lelystad Killed - Oil Netherlands [59] 1988 851 1-24 m 87.05 F, IF, CC
Lelystad Killed - Oil Netherlands [71] 1992 61050 1 m 91.82 F, MC, CC
NCV Killed - Oil Netherlands [72] 1994 337 1 m 79.01 F, IF, CC
NCV Killed - Oil Netherlands [37] 1996 573 1 m 68.14 F, CC
Average 96.02 ± 0.01
Sheep
NCV Live 316F Oil Paraffin Greece [73] 1988 1448 1 m 76.14 F, MC, TM
NCV Live 316F Oil Paraffin Greece [73] 1988 5526 Adults 28.74 F, MC, TM
Lio-Johne Live 316F Oil Spain [74] 1993 1201 Adults 78.29 F, MC, CC
Lio-Johne Live 316F Oil Spain [75] 1995 570 1 m 52.55 F, MC, TM
Weybridge Live 316F P/O/P U.K. [76] 1993 830 Adults 89.86 F, IF, CC
Neoparasec & NCV Live & Killed 316F
-
Oil
Oil
Spain [77] 1995 857 Adults 54.55 F, IF, CC
Neoparasec Live 316F Oil New Zealand [78] 2000 28 1-1.5 m 71.43 E, MC, CC
Gudair Killed 316F Oil Australia [79] 2003 8000 3, 8 m, 2 y 87.50 F, IF, mort rate
Gudair Killed 316F Oil Australia [80] 2004 1200 1-4 m 90.00 F,MC, mort reduction
Gudair Killed 316F Oil Australia [34] 2006 400 1-3 m 91.25 F, MC, TM
Gudair Killed 316F Oil New Zealand [81] 2009 65 4 m 78.57 E, MC, CA
NCV Killed 316F Lipid-K formulation New Zealand [81] 2009 65 4 m 57.14 E, MC, CA
NCV Live 316F Lipid-K formulation New Zealand [81] 2009 65 4 m 14.29 E, MC, CA
NCV Live 316F Lipid-K formulation New Zealand [81] 2009 65 4 m 35.71 E, MC, CA
Average 67.57% ± 0.35
Goats
NCV Live 316F Oil Paraffin Greece [73] 1988 2178 1 m 82.78 F, MC, TM
NCV Live 316F Oil Paraffin Greece [73] 1988 7773 Adults 34.52 F, MC, TM
Average 45.08 ± 0.39
  1. NCV: non-commercial vaccine; Weybridge: Central Veterinary Laboratory, Weybridge, UK; Fromm: Fromm Laboratories, Grafton, Wisconsin USA; Lelystad: Central Veterinary Institute, Lelystad, The Netherlands; Lio-Johne, Ovejero, Spain; Neoparasec: Neoparasec®, Merial; Gudair: Gudair®, CZ Veterinaria/Pfizer; P/O/P Paraffin, Olive Oil, Pumice Stone Powder; y: year(s); m: month(s); w: week(s); d: day(s); F: Field trial; E: Experimental infection; MC: Comparison to matched controls; IF: Comparison of initial versus final prevalence; TM: Total mortality; CC: clinical cases; NVH: Comparison to non-vaccinating herds.
\