From: Paratuberculosis control: a review with a focus on vaccination
Vaccine | Country and reference | Year | Number of animals | Age at vaccination | Reduction (%) | Type of trial | |||
---|---|---|---|---|---|---|---|---|---|
Name/Laboratory | Type | Strain/Antigen | Adjuvant | Â | Â | Â | Â | Â | Â |
Cattle | |||||||||
NCV | Live | 6 strains | Oil | U.S.A. [65] | 1935 | 20 | 1 m | -14.29 | E,TC |
Weybridge | Live | 316F | P/O/P | U.K. [68] | 1965 | 84 | 1 w | 11.54 | E, MC, TC |
Weybridge | Live | 316F | P/O/P | Australia [82] | 1971 | 82 | 1 m | 24.18 | F, IF,MC, TC |
NCV | Live | avirulent | P/O/P | U.S.A. [83] | 1974 | 16 | 16 d | 81.47 | E, MC, FC |
NCV | Live | avirulent | P/O/P | U.S.A. [83] | 1974 | 16 | 16 d | 0.00 | E, MC, TC |
Fromm | Killed | M.a.a strain 18 | Oil | U.S.A.[70] | 1983 | 158 | 1 m | 79.28 | F, MC, FC |
Fromm | Killed | M.a.a strain 18 | Oil | U.S.A. [70] | 1983 | 3060 | 1 m | 99.11 | F, IF, FC |
NCV | Live | 316F | Oil | Denmark [84] | 1983 | 5446 | 1 m | 92.90 | F, MC, FC |
Lelystad | Killed | - | Oil | Netherlands [71] | 1992 | 2065 | 1 m | -21.25 | F, IF, FC |
NCV | Live | 316F | P/O/P | France [85] | 1992 | 22988 | 1 m | 81.68 | F, IF/MC, FC |
Phylaxia | Killed | 5889 Bergey | Oil | Hungary [86] | 1994 | 2738 | 1 m | 94.70 | F, IF, FC |
NCV | Killed | - | Oil | Netherlands [72] | 1994 | 499 | 1 m | -36.72 | F, IF, TC |
NCV | Killed | - | Oil | Netherlands [37] | 1996 | 573 | 1 m | 13.34 | F, IF, TC |
Mycopar | Killed | M.a.a strain 18 | Oil | U.S.A.[87] | 2000 | 372 | < 35 d | 71.43 | F, MC, FC |
NCV | Killed | - | Oil | Netherlands [88] | 2001 | 4452 | 1 m | 33.83 | F, NVH, FC |
Neoparasec | Live | 316F | Oil | Germany [89] | 2002 | 521 | 1 m | 86.87 | F, MC, FC |
Mycopar | Killed | M.a.a strain 18 | Oil | U.S.A. [58] | 2003 | 10 | 7 d | -28.00 | E, MC, FC, TC |
Mycopar IL-12 | Killed | M.a.a strain 18 | Oil | U.S.A. [58] | 2003 | 10 | 7 d | 32.00 | E, MC, FC, TC |
Mycopar | Killed | M.a.a strain 18 | Oil | U.S.A. [58] | 2003 | 14 | 8 d | 40.00 | E, MC, FC, TC |
Mycopar IL-12 | Killed | M.a.a strain 18 | Oil | U.S.A. [58] | 2003 | 14 | 8 d | 23.60 | E, MC, FC, TC |
Silirum | Killed | 316F | Oil | Spain [90] | 2005 | 14 | 2 m | 62.50 | E, MC, TC |
NCV | Rec | Hsp70 | DDA | Netherlands [39] | 2006 | 20 | 1 m boost 11 m | 37.50 | E, MC, FC |
Mycopar | Killed | M.a.a strain 18 | Oil | U.S.A. [91] | 2006 | 213 | < 35 d | 77.12 | F, MC, FC |
NCV | Rec | MAP (85A, 85B, 85C, SOD) | MPLA +/- IL12 RIBI | U.S.A. [92] | 2008 | 24 | 5-10 d | 41.67 | E, MC, FC, TC |
Silirum | Killed | 316F | Oil | U.S.A. [93] | 2009 | 12 | 14 d | 84.61 | E,MC,TC |
Silirum | Killed | 316F | Oil | Spain [49] | 2009 | 371 | all ages | 68.20 | F, IF, FC, FP |
Average | 72.55 ± 0.29 | ||||||||
Sheep | |||||||||
NCV | Killed | 101 sheep & VB/4 cattle | Oil | U.K. [94] | 1961 | 44 | 1 m | 52.63 | E, MC, TC |
NCV | Killed | - | Oil | U.K. [95] | 1962 | 126 | 1 m | 29.05 | E, MC, TC |
Lio-Johne | Live | 316F | Oil | Spain [74] | 1993 | 1201 | Adults | 80.01 | F, MC, TC |
Neoparasec | Live | 316F | Oil | Spain [96] | 1994 | 13 | 2 m | 38.89 | E, MC, TC |
Neoparasec & NCV | Live & Killed | 316F - | Oil | Spain [77] | 1995 | 97 | Adults | -10.95 | F, IF, TC |
NCV | Killed | - | Oil Paraffin | Greece [97] | 1997 | 226 | 1 m | 93.27 | F, MC, FC |
Neoparasec | Live | 316F | Oil | New Zealand [78] | 2000 | 28 | 1-1.5 m | 66.67 | E, MC, TP |
Gudair | Killed | 316F | Oil | Australia [80] | 2004 | 1200 | 1-4 m | 90.00 | F, MC, FC |
Gudair | Killed | 316F | Oil | Australia [98] | 2005 | - | 16 w | 52.21 | F, IF, FC |
Gudair | Killed | 316F | Oil | Australia [34] | 2006 | 400 | 1 m | 76.14 | F, MC, FC |
Gudair | Killed | 316F | Oil | Australia [34] | 2006 | 400 | 1 m | 84.15 | F, MC, FC |
Gudair | Killed | 316F | Oil | Australia [99] | 2007 | 998 | 2-3 m | 76.14 | F, MC, FC |
Gudair | Killed | 316F | Oil | New Zealand [81] | 2009 | 62 | 4 m | 25.30 | E, MC, FC |
NCV | Killed | 316F | Lipid-K formulation | New Zealand [81] | 2009 | 63 | 4 m | 36.03 | E, MC, FC |
NCV | Live | 316F | Lipid-K formulation | New Zealand [81] | 2009 | 63 | 4 m | 36.03 | E, MC, FC |
NCV | Live | 316F | Lipid-K formulation | New Zealand [81] | 2009 | 62 | 4 m | 34.09 | E, MC, FC |
Average | 76.42 ± 0.54 | ||||||||
Goats | |||||||||
Neoparasec | Live | 316F | Oil | France [100] | 1988 | 27 | 1 m | 73.08 | E, MC, FC |
Neoparasec | Live | 316F | Oil | France [100] | 1988 | 26 | 1 m | 51.01 | E, MC, TC |
Fromm | Killed | - | Freund's Complete | U.S.A. [101] | 1988 | 1075 | 1 m | 80.23 | F, MC, FC |
NCV | Killed | - | Oil Paraffin | Greece [97] | 1997 | 297 | 1 m | 95.57 | F, NVH, FC |
NCV | Killed | Goat isolate (CWD) | QS21 | U.S.A. [102] | 2007 | 20 | 1-4 w | 61.69 | E, MC, FC, TC |
NCV | Killed | Goat isolate (CWC) | QS21 | U.S.A. [102] | 2007 | 20 | 1-4 w | 85.19 | E, MC, FC, TC |
NCV | Killed | Goat isolate (CWC) | Alum | U.S.A. [102] | 2007 | 20 | 1-4 w | 79.31 | E, MC, FC, TC |
NCV | Killed | Goat isolate (CWD) | Alum | U.S.A. [102] | 2007 | 20 | 1-4 w | -57.68 | E, MC, FC, TC |
NCV | Killed | Virulent Field Strain | Alum | India [48] | 2007 | 55 | 4-6 m | 82.14 | E, MC, FC |
Gudair | Killed | 316F | Oil | India [48] | 2007 | 55 | 4-6 m | 52.38 | E, MC, FC |
NCV | Rec | MAP (85A, 85B, SOD, 74F) | DDA | U.S.A. [40] | 2009 | 17 | 5-10 d | 87.50 | E, MC, TC |
NCV | Rec | MAP (85A, 85B, SOD, 74F) | none | U.S.A. [40] | 2009 | 17 | 5-10 d | 37.50 | E, MC, TC |
Average | 79.34 ± 0.89 |