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Table 4 Epidemiological effects (Mycobacterium avium subsp. paratuberculosis isolation from faeces or tissues).

From: Paratuberculosis control: a review with a focus on vaccination

Vaccine Country and reference Year Number of animals Age at vaccination Reduction (%) Type of trial
Name/Laboratory Type Strain/Antigen Adjuvant       
Cattle
NCV Live 6 strains Oil U.S.A. [65] 1935 20 1 m -14.29 E,TC
Weybridge Live 316F P/O/P U.K. [68] 1965 84 1 w 11.54 E, MC, TC
Weybridge Live 316F P/O/P Australia [82] 1971 82 1 m 24.18 F, IF,MC, TC
NCV Live avirulent P/O/P U.S.A. [83] 1974 16 16 d 81.47 E, MC, FC
NCV Live avirulent P/O/P U.S.A. [83] 1974 16 16 d 0.00 E, MC, TC
Fromm Killed M.a.a strain 18 Oil U.S.A.[70] 1983 158 1 m 79.28 F, MC, FC
Fromm Killed M.a.a strain 18 Oil U.S.A. [70] 1983 3060 1 m 99.11 F, IF, FC
NCV Live 316F Oil Denmark [84] 1983 5446 1 m 92.90 F, MC, FC
Lelystad Killed - Oil Netherlands [71] 1992 2065 1 m -21.25 F, IF, FC
NCV Live 316F P/O/P France [85] 1992 22988 1 m 81.68 F, IF/MC, FC
Phylaxia Killed 5889 Bergey Oil Hungary [86] 1994 2738 1 m 94.70 F, IF, FC
NCV Killed - Oil Netherlands [72] 1994 499 1 m -36.72 F, IF, TC
NCV Killed - Oil Netherlands [37] 1996 573 1 m 13.34 F, IF, TC
Mycopar Killed M.a.a strain 18 Oil U.S.A.[87] 2000 372 < 35 d 71.43 F, MC, FC
NCV Killed - Oil Netherlands [88] 2001 4452 1 m 33.83 F, NVH, FC
Neoparasec Live 316F Oil Germany [89] 2002 521 1 m 86.87 F, MC, FC
Mycopar Killed M.a.a strain 18 Oil U.S.A. [58] 2003 10 7 d -28.00 E, MC, FC, TC
Mycopar
IL-12
Killed M.a.a strain 18 Oil U.S.A. [58] 2003 10 7 d 32.00 E, MC, FC, TC
Mycopar Killed M.a.a strain 18 Oil U.S.A. [58] 2003 14 8 d 40.00 E, MC, FC, TC
Mycopar
IL-12
Killed M.a.a strain 18 Oil U.S.A. [58] 2003 14 8 d 23.60 E, MC, FC, TC
Silirum Killed 316F Oil Spain [90] 2005 14 2 m 62.50 E, MC, TC
NCV Rec Hsp70 DDA Netherlands [39] 2006 20 1 m
boost 11 m
37.50 E, MC, FC
Mycopar Killed M.a.a strain 18 Oil U.S.A. [91] 2006 213 < 35 d 77.12 F, MC, FC
NCV Rec MAP (85A, 85B, 85C, SOD) MPLA +/- IL12 RIBI U.S.A. [92] 2008 24 5-10 d 41.67 E, MC, FC, TC
Silirum Killed 316F Oil U.S.A. [93] 2009 12 14 d 84.61 E,MC,TC
Silirum Killed 316F Oil Spain [49] 2009 371 all ages 68.20 F, IF, FC, FP
Average 72.55 ± 0.29
Sheep
NCV Killed 101 sheep & VB/4 cattle Oil U.K. [94] 1961 44 1 m 52.63 E, MC, TC
NCV Killed - Oil U.K. [95] 1962 126 1 m 29.05 E, MC, TC
Lio-Johne Live 316F Oil Spain [74] 1993 1201 Adults 80.01 F, MC, TC
Neoparasec Live 316F Oil Spain [96] 1994 13 2 m 38.89 E, MC, TC
Neoparasec & NCV Live & Killed 316F
-
Oil Spain [77] 1995 97 Adults -10.95 F, IF, TC
NCV Killed - Oil Paraffin Greece [97] 1997 226 1 m 93.27 F, MC, FC
Neoparasec Live 316F Oil New Zealand [78] 2000 28 1-1.5 m 66.67 E, MC, TP
Gudair Killed 316F Oil Australia [80] 2004 1200 1-4 m 90.00 F, MC, FC
Gudair Killed 316F Oil Australia [98] 2005 - 16 w 52.21 F, IF, FC
Gudair Killed 316F Oil Australia [34] 2006 400 1 m 76.14 F, MC, FC
Gudair Killed 316F Oil Australia [34] 2006 400 1 m 84.15 F, MC, FC
Gudair Killed 316F Oil Australia [99] 2007 998 2-3 m 76.14 F, MC, FC
Gudair Killed 316F Oil New Zealand [81] 2009 62 4 m 25.30 E, MC, FC
NCV Killed 316F Lipid-K formulation New Zealand [81] 2009 63 4 m 36.03 E, MC, FC
NCV Live 316F Lipid-K formulation New Zealand [81] 2009 63 4 m 36.03 E, MC, FC
NCV Live 316F Lipid-K formulation New Zealand [81] 2009 62 4 m 34.09 E, MC, FC
Average 76.42 ± 0.54
Goats
Neoparasec Live 316F Oil France [100] 1988 27 1 m 73.08 E, MC, FC
Neoparasec Live 316F Oil France [100] 1988 26 1 m 51.01 E, MC, TC
Fromm Killed - Freund's Complete U.S.A. [101] 1988 1075 1 m 80.23 F, MC, FC
NCV Killed - Oil Paraffin Greece [97] 1997 297 1 m 95.57 F, NVH, FC
NCV Killed Goat isolate (CWD) QS21 U.S.A. [102] 2007 20 1-4 w 61.69 E, MC, FC, TC
NCV Killed Goat isolate (CWC) QS21 U.S.A. [102] 2007 20 1-4 w 85.19 E, MC, FC, TC
NCV Killed Goat isolate (CWC) Alum U.S.A. [102] 2007 20 1-4 w 79.31 E, MC, FC, TC
NCV Killed Goat isolate (CWD) Alum U.S.A. [102] 2007 20 1-4 w -57.68 E, MC, FC, TC
NCV Killed Virulent Field Strain Alum India [48] 2007 55 4-6 m 82.14 E, MC, FC
Gudair Killed 316F Oil India [48] 2007 55 4-6 m 52.38 E, MC, FC
NCV Rec MAP (85A, 85B, SOD, 74F) DDA U.S.A. [40] 2009 17 5-10 d 87.50 E, MC, TC
NCV Rec MAP (85A, 85B, SOD, 74F) none U.S.A. [40] 2009 17 5-10 d 37.50 E, MC, TC
Average 79.34 ± 0.89
  1. NCV: non-commercial vaccine; Weybridge: Central Veterinary Laboratory, Weybridge, UK; Fromm: Fromm Laboratories, Grafton, Wisconsin USA; Lelystad: Central Veterinary Institute, Lelystad, The Netherlands; Phylaxia: Phylaxia Veterinary Biologicals Company, Budapest; Mycopar®: Mycopar Fort Doge/Solvay, USA; Neoparasec: Neoparasec®, Merial; Silirum: Silirum®, CZ Veterinaria/Pfizer; Lio-Johne, Ovejero, Spain; Gudair: Gudair®, CZ Veterinaria/Pfizer; Rec: recombinant; CWD Cell Wall Deficient MAP; CWC Cell Wall Competent MAP; P/O/P Paraffin, Olive Oil, Pumice Stone Powder; y: year(s); m: month(s); w: week(s); d: day(s); F: Field trial; E: Experimental infection; MC: Comparison to matched controls; IF: Comparison of initial versus final prevalence; NVH: Comparison to non-vaccinating herds; TC: Tissue culture; FC: Fecal culture.
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