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Table 5 Pathogenetic effects (histopathological lesions).

From: Paratuberculosis control: a review with a focus on vaccination

Vaccine Country and reference Year Number of animals Age at vaccination Reduction (%) Type of trial
Name/Laboratory Type Strain/Antigen Adjuvant       
Cattle
NCV Live 6 strains Oil U.S.A. [65] 1935 20 calves 42.86 E, HP
NCV Live avirulent P/O/P U.S.A. [83] 1974 16 16 d 17.24 E, HP
Lelystad Killed - None Netherlands [71] 1992 3209 1 m 58.34 F, IF, HP
NCV Killed - Oil Netherlands [72] 1994 499 1 m 57.23 F, IF, HP
NCV Killed - Oil Netherlands [37] 1996 573 1 m 58.09 F, IF, HP
Silirum Killed 316F Oil Spain [103] 2005 79 all ages 38.68 F, MC, HP
Silirum Killed 316F Oil Spain [90] 2005 14 2 m 37.50 E, MC, HP
Average 57.54 ± 0.11
Sheep
NCV Killed - Oil Iceland [54] 1960 419 3 m 83.58 F, MC, PM
NCV Killed - Oil Iceland [54] 1960 24323 3 m 93.55 F, MC, PM
NCV Killed   Oil U.K. [95] 1962 126 1 m 52.22 E, MC, HP
Lio-Johne Live 316F Oil Spain [74] 1993 570 1 m 100.00 F, MC, HP
Lio-Johne Live 316F Oil Spain [74] 1993 1201 Adults 53.36 F, MC, HP
Neoparasec Live 316F Oil Spain [96] 1994 13 2 m 64.52 E, MC, HP
Neoparasec Live 316F Oil Australia [104] 1995 475 3 m 82.27 F, MC. HP
Neoparasec & Gudair Live and Killed 316F Oil Spain [77] 1995 135 Adults -3.03 F, IF, HP,
Neoparasec Live 316F Oil New Zealand [78] 2000 28 1-1.5 m 77.78 E, MC, HP
Gudair Killed 316F Oil Spain [105] 2002 12 1 m 100.00 E, MC, HP
Mycopar Killed M.a.a.
Strain 18
Oil U.S.A. [106] 2005 178 60-164 d 75.31 F, MC, HP
Neoparasec Live 316F Oil New Zealand [57] 2005 59 2-4 w 68.52 E, MC, HP
AquaVax Live 316F saline New Zealand [57] 2005 58 2-4 w -2.48 E, MC, HP
Gudair Killed 316F Oil Australia [34] 2006 88 1-3 m 72.70 F, MC, GL, HP
Gudair Killed 316F Oil Australia [34] 2006 307 1-3 m 48.29 F, MC, GL, HP
Gudair Killed 316F Oil New Zealand [81] 2009 62 4 m 75.57 E, MC, HP
NCV Killed 316F Lipid-K formulation New Zealand [81] 2009 63 4 m 37.17 E, MC, HP
NCV Live 316F Lipid-K formulation New Zealand [81] 2009 63 4 m 51.32 E, MC, HP
NCV Live 316F Lipid-K formulation New Zealand [81] 2009 62 4 m 57.56 E, MC, HP
Average 89.70 ± 0.15
Goats
NCV Live 2E/316F P/O/P Norway [26] 1985 5535 1 m 97.18 F, IF, PM
Gudair Killed 316F Oil Spain [38] 2000 189 Adults 65.88 F, MC, HP
NCV Killed Goat isolate (CWD) QS21 U.S.A. [102] 2007 20 1 w 34.38 E, MC, HP
NCV Killed Goat isolate (CWC) QS21 U.S.A. [102] 2007 20 1 w 32.03 E, MC, HP
NCV Killed Goat isolate (CWC) Alum U.S.A. [102] 2007 20 1 w 44.53 E, MC, HP
NCV Killed Goat isolate (CWD) Alum U.S.A. [102] 2007 20 1 w -17.19 E, MC, HP
NCV Killed Virulent Field Strain Alum India [48] 2007 8 4-6 m 75.00 E, MC, HP
Gudair Killed 316F Oil India [48] 2007 8 4-6 m 50.00 E, MC, HP
NCV Rec MAP(85A, 85B, SOD, 74F) DDA U.S.A. [40] 2009 17 5-10 d 66.67 E, MC, HP
NCV Rec MAP(85A, 85B, SOD, 74F) none U.S.A. [40] 2009 17 5-10 d 33.33 E, MC, HP
Average 94.79% ± 0.29
  1. NCV: non-commercial vaccine; Lelystad: Central Veterinary Institute, Lelystad, The Netherlands; Silirum: Silirum®, CZ Veterinaria/Pfizer; Lio-Johne, Ovejero, Spain; Neoparasec: Neoparasec®, Merial; Gudair: Gudair®, CZ Veterinaria/Pfizer; Mycopar®: Mycopar Fort Doge/Solvay, USA; AquaVax; Rec: recombinant; CWD Cell Wall Deficient MAP; CWC Cell Wall Competent MAP; P/O/P Paraffin, Olive Oil, Pumice Stone Powder; y: year(s); m: month(s); w: week(s); d: day(s); F: Field trial; E: Experimental infection; MC: Comparison to matched controls; IF: Comparison of initial versus final prevalence; GL: Gross lesions; HL: Histological lesions.
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