Articles

Psoriatic arthritis: Pathogenesis and novel immunomodulatory approaches to treatment

Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy characterized by the association of arthritis and psoriasis. PsA runs a variable course, from mild synovitis to severe, progressive, erosive arth...

Authors: Sarah Cassell and Arthur Kavanaugh

The significance of glucose, insulin and potassium for immunology and oncology: a new model of immunity

A recent development in critical care medicine makes it urgent that research into the effect of hormones on immunity be pursued aggressively. Studies have demonstrated a large reduction in mortality as a resul...

Authors: Albert F Hill, William J Polvino and Darcy B Wilson

Rapid construction of a dendritic cell vaccine through physical perturbation and apoptotic malignant T cell loading

We have demonstrated that adherence and release of monocytes from a plastic surface drives their differentiation into immature dendritic cells (DC,) that can mature further during overnight incubation in the p...

Authors: Maria Salskov-Iversen, Carole L Berger and Richard L Edelson

Granulocyte-macrophage colony-stimulating factor as an immune-based therapy in HIV infection

The HIV/AIDS epidemic continues to spread despite more than 20 years of significant research and major advances in its treatment. The introduction of highly active antiretroviral therapy in recent years has si...

Authors: Pierre Antoine Brown and Jonathan B Angel

Kinetics and isotype profile of antibody responses in rhesus macaques induced following vaccination with HPV 6, 11, 16 and 18 L1-virus-like particles formulated with or without Merck aluminum adjuvant

Human papillomaviruses (HPV) are the most common sexually transmitted viruses. Infection of the cervical epithelium by HPVs can lead to the development of cervical cancer. Recent advances in vaccine research h...

Authors: Wanda Ruiz, William L McClements, Kathrin U Jansen and Mark T Esser

BCG vaccination at three different age groups: response and effectiveness

The protection, which some BCG vaccines could confer against the development of tuberculosis (TB) in childhood, might be indirectly reflected by the subsequent development of BCG immune response. The objective...

Authors: George Briassoulis, Irene Karabatsou, Vasilis Gogoglou and Athina Tsorva

Antigenized antibodies expressing Vβ8.2 TCR peptides immunize against rat experimental allergic encephalomyelitis

Immunity against the T cell receptor (TCR) is considered to play a central role in the regulation of experimental allergic encephalomyelitis (EAE), a model system of autoimmune disease characterized by a restr...

Authors: Cristina Musselli, Svetlana Daverio-Zanetti and Maurizio Zanetti

Identification of proteases employed by dendritic cells in the processing of protein purified derivative (PPD)

Dendritic cells (DC) are known to present exogenous protein Ag effectively to T cells. In this study we sought to identify the proteases that DC employ during antigen processing. The murine epidermal-derived D...

Authors: Mansour Mohamadzadeh, Hamid Mohamadzadeh, Melissa Brammer, Karol Sestak and Ronald B Luftig

Tumor-infiltrating effector cells of α-galactosylceramide-induced antitumor immunity in metastatic liver tumor

α-Galactosylceramide (α-GalCer) can be presented by CD1d molecules of antigen-presenting cells, and is known to induce a potent NKT cell-dependent cytotoxic response against tumor cells. However, the main effe...

Authors: Takuya Osada, Hirokazu Nagawa and Yoichi Shibata

Association of the T allele of an intronic single nucleotide polymorphism in the colony stimulating factor 1 receptor with Crohn's disease: a case-control study

Polymorphisms in several genes (NOD2, MDR1, SLC22A4) have been associated with susceptibility to Crohn's disease. Identification of the remaining Crohn's susceptibility genes is essential for the development o...

Authors: Adriana Zapata-Velandia, San-San Ng, Rebecca F Brennan, Neal R Simonsen, Mariella Gastanaduy, Jovanny Zabaleta, Jennifer J Lentz, Randall D Craver, Hernan Correa, Alberto Delgado, Angela L Pitts, Jane R Himel, John N Udall Jr, Eberhard Schmidt-Sommerfeld, Raynorda F Brown, Grace B Athas…

Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed

Potent anthrax toxin neutralizing human monoclonal antibodies were generated from peripheral blood lymphocytes obtained from Anthrax Vaccine Adsorbed (AVA) immune donors. The anti-anthrax toxin human monoclona...

Authors: Ritsuko Sawada-Hirai, Ivy Jiang, Fei Wang, Shu Man Sun, Rebecca Nedellec, Paul Ruther, Alejandro Alvarez, Diane Millis, Phillip R Morrow and Angray S Kang

Current problems of perinatal Chlamydia trachomatisinfections

Chlamydia trachomatis has been recognized as a pathogen of trachoma, nongonococcal urethritis, salpingitis, endocervicitis, pelvic inflammatory disease, inclusion conjunctivitis of neonates, follicular conjunctiv...

Authors: Kei Numazaki

The effects of chemotherapeutics on cellular metabolism and consequent immune recognition

A widely held view is that oncolytic agents induce death of tumor cells directly. In this report we review and discuss the apoptosis-inducing effects of chemotherapeutics, the effects of chemotherapeutics on m...

Authors: M Karen Newell, Robert Melamede, Elizabeth Villalobos-Menuey, Douglas Swartzendruber, Richard Trauger, Robert E Camley and William Crisp

Development of a model of focal pneumococcal pneumonia in young rats

A recently licensed pneumococcal conjugate vaccine has been shown to be highly effective in the prevention of bacteremia in immunized children but the degree of protection against pneumonia has been difficult ...

Authors: Richard Malley, Anne M Stack, Robert N Husson, Claudette M Thompson, Gary R Fleisher and Richard A Saladino

Dendritic cells: In the forefront of immunopathogenesis and vaccine development – A review

Dendritic cellls (DCs) comprise an essential component of the immune system. These cells, as antigen presenting cells (APCs) to naïve T cells, are crucial in the initiation of antigen specific immune responses...

Authors: Mansour Mohamadzadeh and Ronald Luftig

Generating neutralizing antibodies, Th1 response and MHC non restricted immunogenicity of HIV-I env and gagpeptides in liposomes and ISCOMs with in-built adjuvanticity

For enhancing immunogenicity and develop vaccine strategies using peptide based constructs against HIV-1, a chimeric peptide containing V3 loop and transmembrane sequence of gp41 with two glycine motifs as spa...

Authors: Lokesh Agrawal, W Haq, Carl Veith Hanson and D Nageswara Rao

Welcome to the Journal of Immune Based Therapies and Vaccines (JIBTV)

Authors: Ronald B Moss

A Canadian national survey of attitudes and knowledge regarding preventive vaccines

Vaccines have virtually eliminated many diseases, but public concerns about their safety could undermine future public health initiatives.

Authors: Paul Ritvo, Jane Irvine, Neil Klar, Kumanan Wilson, Laura Brown, Karen E Bremner, Aline Rinfret, Robert Remis and Murray D Krahn

Effects of monoclonal anti-PcrV antibody on Pseudomonas aeruginosa-induced acute lung injury in a rat model

The effects of the murine monoclonal anti-PcrV antibody Mab166 on acute lung injury induced by Pseudomonas aeruginosa were analyzed in a rat model.

Authors: Karine Faure, Junichi Fujimoto, David W Shimabukuro, Temitayo Ajayi, Nobuaki Shime, Kiyoshi Moriyama, Edward G Spack, Jeanine P Wiener-Kronish and Teiji Sawa

Tumor–associated antigens identified by mRNA expression profiling as tumor rejection epitopes

Thirteen H-2^b-binding peptides derived from six potentially overexpressed proteins in p53^-/- thymoma (SM7) cells were studied for immunogenecity and vaccine-induced prevention of tumor growth in mice inoculated w...

Authors: Marie Louise Andersen, Morten Ruhwald, Mette Thorn, Anders Elm Pedersen, Susanne Mathiassen, Soren Buus and Mogens H Claesson