| | | |
Severity of Disease*
|
|---|
|
Group
|
No. Rats
|
Immunogen
|
Incidence
|
Max Score (mean ± SD)
|
Duration (mean ± SD)
|
Disease Index
|
|---|
|
I
|
6
|
γ2bTCR-I
|
6/6
|
2.5 ± 0.8a
|
4.2 ± 0.4b
|
10.5
|
|
II
|
6
|
γ2bWT
|
6/6
|
3.0 ± 1.3
|
5.7 ± 1.7
|
17.1
|
|
III
|
2
|
CFA
|
2/2
|
4
|
6
|
24
|
|
IV
|
3
|
-
|
3/3
|
4
|
7.3 ± 0.6
|
29.2
|
- * EAE was scored according to incidence, severity and duration. Disease index was calculated as follows: Mean Maximum Score × Mean Duration of Disease × Incidence.
- Significance: (a) Group I vs Group II p = 0.394 and Group I vs Group IV p = 0.051; (b) Group I vs Group III p = 0.05 and Group I vs Group IV p = 0.026.
