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Table 3 Protection against EAE by vaccination with antigenized antibodies with a murine γ2b constant region

From: Antigenized antibodies expressing Vβ8.2 TCR peptides immunize against rat experimental allergic encephalomyelitis

   

Severity of Disease*

Group

No. Rats

Immunogen

Incidence

Max Score (mean ± SD)

Duration (mean ± SD)

Disease Index

I

6

γ2bTCR-I

6/6

2.5 ± 0.8a

4.2 ± 0.4b

10.5

II

6

γ2bWT

6/6

3.0 ± 1.3

5.7 ± 1.7

17.1

III

2

CFA

2/2

4

6

24

IV

3

-

3/3

4

7.3 ± 0.6

29.2

  1. * EAE was scored according to incidence, severity and duration. Disease index was calculated as follows: Mean Maximum Score × Mean Duration of Disease × Incidence.
  2. Significance: (a) Group I vs Group II p = 0.394 and Group I vs Group IV p = 0.051; (b) Group I vs Group III p = 0.05 and Group I vs Group IV p = 0.026.