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Table 3 Protection against EAE by vaccination with antigenized antibodies with a murine γ2b constant region

From: Antigenized antibodies expressing Vβ8.2 TCR peptides immunize against rat experimental allergic encephalomyelitis

    Severity of Disease*
Group No. Rats Immunogen Incidence Max Score (mean ± SD) Duration (mean ± SD) Disease Index
I 6 γ2bTCR-I 6/6 2.5 ± 0.8a 4.2 ± 0.4b 10.5
II 6 γ2bWT 6/6 3.0 ± 1.3 5.7 ± 1.7 17.1
III 2 CFA 2/2 4 6 24
IV 3 - 3/3 4 7.3 ± 0.6 29.2
  1. * EAE was scored according to incidence, severity and duration. Disease index was calculated as follows: Mean Maximum Score × Mean Duration of Disease × Incidence.
  2. Significance: (a) Group I vs Group II p = 0.394 and Group I vs Group IV p = 0.051; (b) Group I vs Group III p = 0.05 and Group I vs Group IV p = 0.026.