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  1. Content type: Review

    Mycobacterium avium subsp. paratuberculosis (MAP) infection causes in ruminants a regional chronic enteritis that is increasingly being recognized as a significant problem affecting animal health, farming and the...

    Authors: Felix Bastida and Ramon A Juste

    Citation: Journal of Immune Based Therapies and Vaccines 2011 9:8

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  2. Content type: Original research

    The prognosis of patients with advanced non small cell lung (NSCLC) cancer remains dismal. Epidermal Growth Factor Receptor is over-expressed in many epithelial derived tumors and its role in the development a...

    Authors: Pedro C Rodriguez, Elia Neninger, Beatriz García, Xitlally Popa, Carmen Viada, Patricia Luaces, Gisela González, Agustin Lage, Enrique Montero and Tania Crombet

    Citation: Journal of Immune Based Therapies and Vaccines 2011 9:7

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  3. Content type: Short report

    The induction of sterile immunity and long lasting protection against malaria has been effectively achieved by immunization with sporozoites attenuated by gamma-irradiation or through deletion of genes. For mi...

    Authors: Bruno Douradinha, Melissa van Dijk, Geert-Jan van Gemert, Shahid M Khan, Chris J Janse, Andy P Waters, Robert W Sauerwein, Adrian JF Luty, Bruno Silva-Santos, Maria M Mota and Sabrina Epiphanio

    Citation: Journal of Immune Based Therapies and Vaccines 2011 9:6

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  4. Content type: Original research

    Streptococcus pneumoniae causes widespread morbidity and mortality. Current vaccines contain free polysaccharides or protein-polysaccharide conjugates, and do not induce protection against serotypes that are not ...

    Authors: Harm HogenEsch, Anisa Dunham, Bethany Hansen, Kathleen Anderson, Jean-Francois Maisonneuve and Stanley L Hem

    Citation: Journal of Immune Based Therapies and Vaccines 2011 9:5

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  5. Content type: Original research

    Placebo-controlled, randomized, phase 2b trial was conducted in 34 adults comprising 18 first-diagnosed (52.9%), 6 relapsed (17.6%), and 10 MDR-TB (29.4%) cases to investigate the safety and efficacy of an ora...

    Authors: Dmitry A Butov, Yuri N Pashkov, Anna L Stepanenko, Aleksandra I Choporova, Tanya S Butova, Dendev Batdelger, Vichai Jirathitikal, Aldar S Bourinbaiar and Svetlana I Zaitzeva

    Citation: Journal of Immune Based Therapies and Vaccines 2011 9:3

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  6. Content type: Short report

    We have evaluated an attenuated Listeria monocytogenes (Lm) candidate vaccine vector in nonhuman primates using a delivery regimen relying solely on oral vaccination. We sought to determine the impact of prior Lm...

    Authors: James B Whitney, Saied Mirshahidi, So-Yon Lim, Lauren Goins, Chris C Ibegbu, Daniel C Anderson, Richard B Raybourne, Fred R Frankel, Judy Lieberman and Ruth M Ruprecht

    Citation: Journal of Immune Based Therapies and Vaccines 2011 9:2

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  7. Content type: Original research

    Staphylococcal enterotoxins are considered potential biowarfare agents that can be spread through ingestion or inhalation. Staphylococcal enterotoxin B (SEB) is a widely studied superantigen that can directly ...

    Authors: Brian Drozdowski, Yuhong Zhou, Brad Kline, Jared Spidel, Yin Yin Chan, Earl Albone, Howard Turchin, Qimin Chao, Marianne Henry, Jacqueline Balogach, Eric Routhier, Sina Bavari, Nicholas C Nicolaides, Philip M Sass and Luigi Grasso

    Citation: Journal of Immune Based Therapies and Vaccines 2010 8:9

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  8. Content type: Original research

    Dendritic cells (DCs) play a key role in innate and adaptive immunity but the access to sufficient amount of DCs for basic and translational research has been limited.

    Authors: Shuhong Han, Yichen Wang, Bei Wang, Ekta Patel, Starlyn Okada, Li-Jun Yang, Jan S Moreb and Lung-Ji Chang

    Citation: Journal of Immune Based Therapies and Vaccines 2010 8:8

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  9. Content type: Short report

    Several approaches have been explored to eradicate HIV; however, a multigene vaccine appears to be the best option, given their proven potential to elicit broad, effective responses in animal models. The Pr55Gag ...

    Authors: Sirika Pillay, Enid G Shephard, Ann E Meyers, Anna-Lise Williamson and Edward P Rybicki

    Citation: Journal of Immune Based Therapies and Vaccines 2010 8:7

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  10. Content type: Original research

    We previously demonstrated that polyphosphazenes, particularly PCEP, enhance immune responses in mice immunized subcutaneously and intranasally. The objective of the present study was to investigate the effica...

    Authors: Nelson F Eng, Srinivas Garlapati, Volker Gerdts, Lorne A Babiuk and George K Mutwiri

    Citation: Journal of Immune Based Therapies and Vaccines 2010 8:4

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  11. Content type: Original research

    Tuberculosis (TB) is one of the most prevalent cause of death due to a single pathogen. Bacillus Calmette Guérin (BCG) is the only vaccine available for clinical use that protects against miliary TB; however, ...

    Authors: Rajpal S Kashyap, Aliabbas A Husain, Shweta H Morey, Milind S Panchbhai, Poonam S Deshpande, Hemant J Purohit, Girdhar M Taori and Hatim F Daginawala

    Citation: Journal of Immune Based Therapies and Vaccines 2010 8:3

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  12. Content type: Short report

    Studies have shown that CpG oligodeoxyribonucleotides (ODN) protect mice from various bacterial pathogens, including Burkholderia pseudomallei and Francisella tularensis live vaccine strain (LVS), when administer...

    Authors: David A Rozak, Herbert C Gelhaus, Mark Smith, Mojgan Zadeh, Louis Huzella, David Waag and Jeffrey J Adamovicz

    Citation: Journal of Immune Based Therapies and Vaccines 2010 8:2

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  13. Content type: Short report

    Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conj...

    Authors: Vijay NS Bhagawati-Prasad, Evy De Leenheer, Nadine P Keefe, Lorna A Ryan, Jennifer Carlring and Andrew W Heath

    Citation: Journal of Immune Based Therapies and Vaccines 2010 8:1

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  14. Content type: Original research

    Conserved neutralizing epitopes are considered to be a key role for eliciting broadly neutralizing antibody (NAb). Previously, two conserved neutralizing epitopes of HIV-1 CRF01_AE envelope were identified at ...

    Authors: Apichai Sreepian, Jongruk Permmongkol, Wannee Kantakamalakul, Sontana Siritantikorn, Nattaya Tanlieng and Ruengpung Sutthent

    Citation: Journal of Immune Based Therapies and Vaccines 2009 7:5

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  15. Content type: Original research

    Our group previously demonstrated that a DNA plasmid encoding the mycobacterial 65-kDa heat shock protein (DNA-HSP65) displayed prophylactic and therapeutic effect in a mice model for tuberculosis. This protec...

    Authors: Rubens R Santos, Alexandrina Sartori, Deison S Lima, Patrícia RM Souza, Arlete AM Coelho-Castelo, Vânia LD Bonato and Célio L Silva

    Citation: Journal of Immune Based Therapies and Vaccines 2009 7:4

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  16. Content type: Commentary

    Influenza viruses pose a permanent threat to human populations due to their ability to constantly adapt to impact immunologically susceptible individuals in the forms of epidemic and pandemics through antigeni...

    Authors: Carlos Franco-Paredes, Peter Carrasco and Jose Ignacio Santos Preciado

    Citation: Journal of Immune Based Therapies and Vaccines 2009 7:2

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  17. Content type: Original research

    There is no safe, effective human vaccine against brucellosis. Live attenuated Brucella strains are widely used to vaccinate animals. However these live Brucella vaccines can cause disease and are unsafe for huma...

    Authors: Jerome S Harms, Marina A Durward, Diogo M Magnani and Gary A Splitter

    Citation: Journal of Immune Based Therapies and Vaccines 2009 7:1

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  18. Content type: Original research

    Efficacious immune-based therapy in treated chronic HIV-1 infection requires the induction of virus-specific CD4+ T cells and subsequent maturation and maintenance of specific memory CD8+ T cells. Concomitant dai...

    Authors: Anna A Herasimtschuk, Samantha J Westrop, Graeme J Moyle, Jocelyn S Downey and Nesrina Imami

    Citation: Journal of Immune Based Therapies and Vaccines 2008 6:7

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  19. Content type: Original research

    The gram-positive bacterium Streptococcus pyogenes is a common pathogen of humans that causes invasive infections, toxic-shock syndrome, rheumatic fever, necrotizing fasciitis and other diseases. Detection of ant...

    Authors: Robert G Ulrich

    Citation: Journal of Immune Based Therapies and Vaccines 2008 6:8

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  20. Content type: Original research

    Alterations in serum CXCR3 ligand levels were examined in interstitial cystitis (IC) patients; similar expression patterns in serum as well as CXCR3, CXCR3 ligands, and cytokines expressed by peripheral and lo...

    Authors: Senthilkumar K Sakthivel, Udai P Singh, Shailesh Singh, Dennis D Taub, Kristian R Novakovic and James W Lillard Jr

    Citation: Journal of Immune Based Therapies and Vaccines 2008 6:6

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  21. Content type: Original research

    Combination vaccines reduce the total number of injections required for each component administered separately and generally provide the same level of disease protection. Yet, physical, chemical, and biologica...

    Authors: Garry L Morefield, Ralph F Tammariello, Bret K Purcell, Patricia L Worsham, Jennifer Chapman, Leonard A Smith, Jason B Alarcon, John A Mikszta and Robert G Ulrich

    Citation: Journal of Immune Based Therapies and Vaccines 2008 6:5

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  22. Content type: Original research

    Lack of adequate adjuvancy is a possible explanation for lack of vaccine immunogenecity. Immunostimulatory CpGs are potent vaccine adjuvants and may be an important component of the development vaccines, parti...

    Authors: Jonathan B Angel, Curtis L Cooper, Jennifer Clinch, Charlene D Young, Andreane Chenier, Karl G Parato, Michael Lautru, Heather Davis and Donald W Cameron

    Citation: Journal of Immune Based Therapies and Vaccines 2008 6:4

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  23. Content type: Original research

    Chronic hepatitis C virus (HCV) infection results from weak or absent T cell responses. Pegylated-interferon-alpha (IFN-α) and ribavirin, the standard of care for chronic HCV, have numerous immune effects but ...

    Authors: Curtis L Cooper, Navneet K Ahluwalia, Susan M Efler, Jörg Vollmer, Arthur M Krieg and Heather L Davis

    Citation: Journal of Immune Based Therapies and Vaccines 2008 6:3

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  24. Content type: Original research

    As the eradication of tumor cells in vivo is most efficiently performed by cytolytic T lymphocytes (CTL), various methods for priming tumor-reactive lymphocytes have been developed. In this study, a method of pri...

    Authors: Charles A Gullo, William YK Hwang, Chye K Poh, Melvin Au, Geraline Cow and Gerrard Teoh

    Citation: Journal of Immune Based Therapies and Vaccines 2008 6:2

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  25. Content type: Original research

    Human monocyte-derived DC (mDC) loaded with peptides, protein, tumor cell lysates, or tumor cell RNA, are being tested as vaccines against multiple human malignancies and viral infection with great promise. On...

    Authors: Ryan E Campbell-Anson, Diane Kentor, Yi J Wang, Kathryn M Bushnell, Yufeng Li, Luis M Vence and Laszlo G Radvanyi

    Citation: Journal of Immune Based Therapies and Vaccines 2008 6:1

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  26. Content type: Review

    One needs to think outside of the box, as one of us (Ronald B Luftig) learned from many years as a mathematician, and a biophysicist.

    Authors: Qiu Zhong and Ronald B Luftig

    Citation: Journal of Immune Based Therapies and Vaccines 2007 5:12

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  27. Content type: Original research

    There is a clear need for vaccines and therapeutics for potential biological weapons of mass destruction and emerging diseases. Anthrax, caused by the bacterium Bacillus anthracis, has been used as both a biologi...

    Authors: Cassandra D Kelly, Chris O'Loughlin, Frank B Gelder, Johnny W Peterson, Laurie E Sower and Nick M Cirino

    Citation: Journal of Immune Based Therapies and Vaccines 2007 5:11

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  28. Content type: Original research

    To develop avian influenza H5N1 recombinant protein, the hemagglutinin (HA), neuraminidase (NA), matrix (M), and non-structural (NS1) of avian influenza H5N1 isolates from Thailand were engineered to be expres...

    Authors: Navin Horthongkham, Tananun Srihtrakul, Niracha Athipanyasilp, Sontana Siritantikorn, Wannee Kantakamalakul, Yong Poovorawan and Ruengpung Sutthent

    Citation: Journal of Immune Based Therapies and Vaccines 2007 5:10

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  29. Content type: Original research

    Dendritic cells (DCs) are potent antigen-presenting cells and critical for the priming of CD8+ T cells. Therefore the use of these cells as adjuvant cells has been tested in a large number of experimental and ...

    Authors: Anders E Pedersen and Franca Ronchese

    Citation: Journal of Immune Based Therapies and Vaccines 2007 5:9

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  30. Content type: Original research

    Mycobacterium bovis BCG vaccine has displayed inconsistent efficacy in different trials conducted in various geographical regions. Nevertheless, it significantly reduces the risk of severe childhood tuberculosis ...

    Authors: B Anuradha, CM Santosh, V Hari Sai Priya, G Suman Latha, KJR Murthy and Valluri Vijaya Lakshmi

    Citation: Journal of Immune Based Therapies and Vaccines 2007 5:8

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  31. Content type: Original research

    Monocyte-derived-dendritic-cells (MDDC) are the major DC type used in vaccine-based clinical studies for a variety of cancers. In order to assess whether in vitro differentiated MDDC from cryopreserved PBMC of ca...

    Authors: Smita A Ghanekar, Sonny Bhatia, Joyce J Ruitenberg, Corazon DeLa Rosa, Mary L Disis, Vernon C Maino, Holden T Maecker and Cory A Waters

    Citation: Journal of Immune Based Therapies and Vaccines 2007 5:7

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  32. Content type: Original research

    Fully functional HIV-1-specific CD8 and CD4 effector T-cell responses are vital to the containment of viral activity and disease progression. These responses are lacking in HIV-1-infected patients with progres...

    Authors: Gareth AD Hardy, Nesrina Imami, Mark R Nelson, Ann K Sullivan, Ron Moss, Marlén MI Aasa-Chapman, Brian Gazzard and Frances M Gotch

    Citation: Journal of Immune Based Therapies and Vaccines 2007 5:6

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  33. Content type: Original research

    LAG-3 (CD223) is a natural high affinity ligand for MHC class II. The soluble form (sLAG-3) induces maturation of monocyte-derived dendritic cells in vitro and is used as a potent Th1-like immune enhancer with ma...

    Authors: Chrystelle Brignone, Caroline Grygar, Manon Marcu, Gaëlle Perrin and Frédéric Triebel

    Citation: Journal of Immune Based Therapies and Vaccines 2007 5:5

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  34. Content type: Original research

    The labile nature of live, attenuated varicella-zoster virus (Oka/Merck) requires robust stabilization during virus bulk preparation and vaccine manufacturing in order to preserve potency through storage and a...

    Authors: Vladimir Liska, Stacey A Bigert, Philip S Bennett, David Olsen, Robert Chang and Carl J Burke

    Citation: Journal of Immune Based Therapies and Vaccines 2007 5:4

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  35. Content type: Erratum

    Citation: Journal of Immune Based Therapies and Vaccines 2007 5:3

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    The original article was published in Journal of Immune Based Therapies and Vaccines 2006 4:6

  36. Content type: Original research

    The malignant cells of cutaneous T cell lymphoma (CTCL) display immunogenic peptides derived from the clonal T cell receptor (TCR) providing an attractive model for refinement of anti-tumor immunization method...

    Authors: Joshua D Shofner, Juan G Vasquez, Carole L Berger and Richard L Edelson

    Citation: Journal of Immune Based Therapies and Vaccines 2007 5:2

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  37. Content type: Original research

    Cytosine-phosphate-guanosine oligodeoxynucleotide (CpG-ODN) has been used successfully to induce immune responses against viral and intracellular organisms in mammals. The main objective of this study was to t...

    Authors: M Julia BF Flaminio, Alexandre S Borges, Daryl V Nydam, David W Horohov, Rolf Hecker and Mary Beth Matychak

    Citation: Journal of Immune Based Therapies and Vaccines 2007 5:1

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  38. Content type: Original research

    Despite the benefits of highly active antitretroviral therapy (HAART) for suppressing viral replication in HIV infection, virus persists and rebounds during treatment interruption (TI). This study explored whe...

    Authors: Kenneth H Huang, Marie-Pierre Boisvert, Famane Chung, Maude Loignon, Don Zarowny, Lise Cyr, Emil Toma and Nicole F Bernard

    Citation: Journal of Immune Based Therapies and Vaccines 2006 4:7

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  39. Content type: Original research

    Vaccine efficacy depends significantly on the use of appropriate adjuvant(s) in the formulation. Phytol, a dietary diterpene alcohol, is similar in structure to naturally occurring isoprenoid adjuvants; but li...

    Authors: So-Yon Lim, Matt Meyer, Richard A Kjonaas and Swapan K Ghosh

    Citation: Journal of Immune Based Therapies and Vaccines 2006 4:6

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    The Erratum to this article has been published in Journal of Immune Based Therapies and Vaccines 2007 5:3

  40. Content type: Original research

    Adjuvants are known to significantly enhance vaccine efficacy. However, commercial adjuvants often have limited use because of toxicity in humans. The objective of this study was to determine the comparative e...

    Authors: So-Yon Lim, Adam Bauermeister, Richard A Kjonaas and Swapan K Ghosh

    Citation: Journal of Immune Based Therapies and Vaccines 2006 4:5

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  41. Content type: Original research

    Oral administration of BCG was the route initially used by Calmette and Guérin, but was replaced by intradermal administration in virtually all countries after the Lubeck accident. However, Brazil continued to...

    Authors: Renata Monteiro-Maia, Maria B Ortigão-de-Sampaio, Rosa T Pinho and Luiz RR Castello-Branco

    Citation: Journal of Immune Based Therapies and Vaccines 2006 4:4

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  42. Content type: Original research

    The heat shock protein, Hsp70, has been shown to play an important role in tumour immunity. Vaccination with Hsp70-peptide complexes (Hsp70-PCs), isolated from autologous tumour cells, can induce protective im...

    Authors: Blanca Arnaiz, Laura Madrigal-Estebas, Stephen Todryk, Tharappel C James, Derek G Doherty and Ursula Bond

    Citation: Journal of Immune Based Therapies and Vaccines 2006 4:2

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  43. Content type: Review

    We hypothesize that the energy strategy of a cell is a key factor for determining how, or if, the immune system interacts with that cell. Cells have a limited number of metabolic states, in part, depending on ...

    Authors: M Karen Newell, Elizabeth Villalobos-Menuey, Susan C Schweitzer, Mary-Ellen Harper and Robert E Camley

    Citation: Journal of Immune Based Therapies and Vaccines 2006 4:1

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  44. Content type: Original research

    With the advent of antiretroviral therapy (ART) cases of immune reconstitution inflammatory syndrome (IRIS) have increasingly been reported. IRIS usually occurs in individuals with a rapidly rising CD4 T-cell ...

    Authors: A Pires, M Nelson, AL Pozniak, M Fisher, B Gazzard, F Gotch and N Imami

    Citation: Journal of Immune Based Therapies and Vaccines 2005 3:7

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