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  1. Review

    Paratuberculosis control: a review with a focus on vaccination

    Mycobacterium avium subsp. paratuberculosis (MAP) infection causes in ruminants a regional chronic enteritis that is increasingly being recognized as a significant problem affecting animal health, farming and the...

    Felix Bastida and Ramon A Juste

    Journal of Immune Based Therapies and Vaccines 2011 9:8

    Published on: 31 October 2011

  2. Original research

    Safety, immunogenicity and preliminary efficacy of multiple-site vaccination with an Epidermal Growth Factor (EGF) based cancer vaccine in advanced non small cell lung cancer (NSCLC) patients

    The prognosis of patients with advanced non small cell lung (NSCLC) cancer remains dismal. Epidermal Growth Factor Receptor is over-expressed in many epithelial derived tumors and its role in the development a...

    Pedro C Rodriguez, Elia Neninger, Beatriz García, Xitlally Popa, Carmen Viada, Patricia Luaces, Gisela González, Agustin Lage, Enrique Montero and Tania Crombet

    Journal of Immune Based Therapies and Vaccines 2011 9:7

    Published on: 24 October 2011

  3. Short report

    Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver

    The induction of sterile immunity and long lasting protection against malaria has been effectively achieved by immunization with sporozoites attenuated by gamma-irradiation or through deletion of genes. For mi...

    Bruno Douradinha, Melissa van Dijk, Geert-Jan van Gemert, Shahid M Khan, Chris J Janse, Andy P Waters, Robert W Sauerwein, Adrian JF Luty, Bruno Silva-Santos, Maria M Mota and Sabrina Epiphanio

    Journal of Immune Based Therapies and Vaccines 2011 9:6

    Published on: 17 October 2011

  4. Original research

    Formulation of a killed whole cell pneumococcus vaccine - effect of aluminum adjuvants on the antibody and IL-17 response

    Streptococcus pneumoniae causes widespread morbidity and mortality. Current vaccines contain free polysaccharides or protein-polysaccharide conjugates, and do not induce protection against serotypes that are not ...

    Harm HogenEsch, Anisa Dunham, Bethany Hansen, Kathleen Anderson, Jean-Francois Maisonneuve and Stanley L Hem

    Journal of Immune Based Therapies and Vaccines 2011 9:5

    Published on: 29 July 2011

  5. Original research

    Immunotherapeutic role of Ag85B as an adjunct to antituberculous chemotherapy

    Immunotherapy to enhance the efficiency of the immune response in tuberculosis patients and to eliminate the persisters could be an additional valuable strategy to complement anti-mycobacterial chemotherapy. T...

    Javaid A Sheikh, Gopal K Khuller and Indu Verma

    Journal of Immune Based Therapies and Vaccines 2011 9:4

    Published on: 26 June 2011

  6. Original research

    Phase IIb randomized trial of adjunct immunotherapy in patients with first-diagnosed tuberculosis, relapsed and multi-drug-resistant (MDR) TB

    Placebo-controlled, randomized, phase 2b trial was conducted in 34 adults comprising 18 first-diagnosed (52.9%), 6 relapsed (17.6%), and 10 MDR-TB (29.4%) cases to investigate the safety and efficacy of an ora...

    Dmitry A Butov, Yuri N Pashkov, Anna L Stepanenko, Aleksandra I Choporova, Tanya S Butova, Dendev Batdelger, Vichai Jirathitikal, Aldar S Bourinbaiar and Svetlana I Zaitzeva

    Journal of Immune Based Therapies and Vaccines 2011 9:3

    Published on: 18 January 2011

  7. Short report

    Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeriavaccine in the induction of immune responses against HIV

    We have evaluated an attenuated Listeria monocytogenes (Lm) candidate vaccine vector in nonhuman primates using a delivery regimen relying solely on oral vaccination. We sought to determine the impact of prior Lm...

    James B Whitney, Saied Mirshahidi, So-Yon Lim, Lauren Goins, Chris C Ibegbu, Daniel C Anderson, Richard B Raybourne, Fred R Frankel, Judy Lieberman and Ruth M Ruprecht

    Journal of Immune Based Therapies and Vaccines 2011 9:2

    Published on: 18 January 2011

  8. Original research

    Generation and characterization of high affinity human monoclonal antibodies that neutralize staphylococcal enterotoxin B

    Staphylococcal enterotoxins are considered potential biowarfare agents that can be spread through ingestion or inhalation. Staphylococcal enterotoxin B (SEB) is a widely studied superantigen that can directly ...

    Brian Drozdowski, Yuhong Zhou, Brad Kline, Jared Spidel, Yin Yin Chan, Earl Albone, Howard Turchin, Qimin Chao, Marianne Henry, Jacqueline Balogach, Eric Routhier, Sina Bavari, Nicholas C Nicolaides, Philip M Sass and Luigi Grasso

    Journal of Immune Based Therapies and Vaccines 2010 8:9

    Published on: 21 December 2010

  9. Original research

    Ex vivo development, expansion and in vivoanalysis of a novel lineage of dendritic cells from hematopoietic stem cells

    Dendritic cells (DCs) play a key role in innate and adaptive immunity but the access to sufficient amount of DCs for basic and translational research has been limited.

    Shuhong Han, Yichen Wang, Bei Wang, Ekta Patel, Starlyn Okada, Li-Jun Yang, Jan S Moreb and Lung-Ji Chang

    Journal of Immune Based Therapies and Vaccines 2010 8:8

    Published on: 24 November 2010

  10. Short report

    HIV-1 sub-type C chimaeric VLPs boost cellular immune responses in mice

    Several approaches have been explored to eradicate HIV; however, a multigene vaccine appears to be the best option, given their proven potential to elicit broad, effective responses in animal models. The Pr55Gag ...

    Sirika Pillay, Enid G Shephard, Ann E Meyers, Anna-Lise Williamson and Edward P Rybicki

    Journal of Immune Based Therapies and Vaccines 2010 8:7

    Published on: 19 November 2010

  11. Original research

    Antiviral activity of Engystol® and Gripp-Heel®: an in-vitro assessment

    Infections with respiratory viruses can activate the innate immune response - an important host defence mechanism in the early stage of viral infection. Interferon (IFN) release, triggered by virus infection, ...

    Kerstin Roeska and Bernd Seilheimer

    Journal of Immune Based Therapies and Vaccines 2010 8:6

    Published on: 16 November 2010

  12. Original research

    PCEP enhances IgA mucosal immune responses in mice following different immunization routes with influenza virus antigens

    We previously demonstrated that polyphosphazenes, particularly PCEP, enhance immune responses in mice immunized subcutaneously and intranasally. The objective of the present study was to investigate the effica...

    Nelson F Eng, Srinivas Garlapati, Volker Gerdts, Lorne A Babiuk and George K Mutwiri

    Journal of Immune Based Therapies and Vaccines 2010 8:4

    Published on: 24 August 2010

  13. Original research

    Assessment of immune response to repeat stimulation with BCG vaccine using in vitro PBMC model

    Tuberculosis (TB) is one of the most prevalent cause of death due to a single pathogen. Bacillus Calmette Guérin (BCG) is the only vaccine available for clinical use that protects against miliary TB; however, ...

    Rajpal S Kashyap, Aliabbas A Husain, Shweta H Morey, Milind S Panchbhai, Poonam S Deshpande, Hemant J Purohit, Girdhar M Taori and Hatim F Daginawala

    Journal of Immune Based Therapies and Vaccines 2010 8:3

    Published on: 28 May 2010

  14. Short report

    CpG oligodeoxyribonucleotides protect mice from Burkholderia pseudomallei but not Francisella tularensis Schu S4 aerosols

    Studies have shown that CpG oligodeoxyribonucleotides (ODN) protect mice from various bacterial pathogens, including Burkholderia pseudomallei and Francisella tularensis live vaccine strain (LVS), when administer...

    David A Rozak, Herbert C Gelhaus, Mark Smith, Mojgan Zadeh, Louis Huzella, David Waag and Jeffrey J Adamovicz

    Journal of Immune Based Therapies and Vaccines 2010 8:2

    Published on: 5 February 2010

  15. Short report

    CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis

    Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conj...

    Vijay NS Bhagawati-Prasad, Evy De Leenheer, Nadine P Keefe, Lorna A Ryan, Jennifer Carlring and Andrew W Heath

    Journal of Immune Based Therapies and Vaccines 2010 8:1

    Published on: 4 February 2010

  16. Original research

    HIV-1 neutralization by monoclonal antibody against conserved region 2 and patterns of epitope exposure on the surface of native viruses

    Conserved neutralizing epitopes are considered to be a key role for eliciting broadly neutralizing antibody (NAb). Previously, two conserved neutralizing epitopes of HIV-1 CRF01_AE envelope were identified at ...

    Apichai Sreepian, Jongruk Permmongkol, Wannee Kantakamalakul, Sontana Siritantikorn, Nattaya Tanlieng and Ruengpung Sutthent

    Journal of Immune Based Therapies and Vaccines 2009 7:5

    Published on: 12 October 2009

  17. Original research

    DNA vaccine containing the mycobacterial hsp65 gene prevented insulitis in MLD-STZ diabetes

    Our group previously demonstrated that a DNA plasmid encoding the mycobacterial 65-kDa heat shock protein (DNA-HSP65) displayed prophylactic and therapeutic effect in a mice model for tuberculosis. This protec...

    Rubens R Santos, Alexandrina Sartori, Deison S Lima, Patrícia RM Souza, Arlete AM Coelho-Castelo, Vânia LD Bonato and Célio L Silva

    Journal of Immune Based Therapies and Vaccines 2009 7:4

    Published on: 15 September 2009

  18. Commentary

    The first influenza pandemic in the new millennium: lessons learned hitherto for current control efforts and overall pandemic preparedness

    Influenza viruses pose a permanent threat to human populations due to their ability to constantly adapt to impact immunologically susceptible individuals in the forms of epidemic and pandemics through antigeni...

    Carlos Franco-Paredes, Peter Carrasco and Jose Ignacio Santos Preciado

    Journal of Immune Based Therapies and Vaccines 2009 7:2

    Published on: 7 August 2009

  19. Original research

    Evaluation of recombinant invasive, non-pathogenic Eschericia coli as a vaccine vector against the intracellular pathogen, Brucella

    There is no safe, effective human vaccine against brucellosis. Live attenuated Brucella strains are widely used to vaccinate animals. However these live Brucella vaccines can cause disease and are unsafe for huma...

    Jerome S Harms, Marina A Durward, Diogo M Magnani and Gary A Splitter

    Journal of Immune Based Therapies and Vaccines 2009 7:1

    Published on: 6 January 2009

  20. Original research

    Effects of recombinant human growth hormone on HIV-1-specific T-cell responses, thymic output and proviral DNA in patients on HAART: 48-week follow-up

    Efficacious immune-based therapy in treated chronic HIV-1 infection requires the induction of virus-specific CD4+ T cells and subsequent maturation and maintenance of specific memory CD8+ T cells. Concomitant dai...

    Anna A Herasimtschuk, Samantha J Westrop, Graeme J Moyle, Jocelyn S Downey and Nesrina Imami

    Journal of Immune Based Therapies and Vaccines 2008 6:7

    Published on: 31 October 2008

  21. Original research

    Vaccine based on a ubiquitous cysteinyl protease and streptococcal pyrogenic exotoxin A protects against Streptococcus pyogenessepsis and toxic shock

    The gram-positive bacterium Streptococcus pyogenes is a common pathogen of humans that causes invasive infections, toxic-shock syndrome, rheumatic fever, necrotizing fasciitis and other diseases. Detection of ant...

    Robert G Ulrich

    Journal of Immune Based Therapies and Vaccines 2008 6:8

    Published on: 31 October 2008

  22. Original research

    CXCL10 blockade protects mice from cyclophosphamide-induced cystitis

    Alterations in serum CXCR3 ligand levels were examined in interstitial cystitis (IC) patients; similar expression patterns in serum as well as CXCR3, CXCR3 ligands, and cytokines expressed by peripheral and lo...

    Senthilkumar K Sakthivel, Udai P Singh, Shailesh Singh, Dennis D Taub, Kristian R Novakovic and James W Lillard Jr

    Journal of Immune Based Therapies and Vaccines 2008 6:6

    Published on: 28 October 2008

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