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Table 1 Neutralizing antibody titer (NT titer) (geometric mean) of sera from immunized mice against heterologous H5N1 influenza virus (A/Thailand/1/RPNP/2005). Sera from 5 groups of 5 mice per recombinant protein immunization were collected 1 week after last immunization with 250 μg of recombinant HA or NA, or NS1 or M proteins. Mann-Whitney method

From: Specific antibody response of mice after immunization with COS-7 cell derived avian influenza virus (H5N1) recombinant proteins

Recombinant proteins Neutralization titer ELISA titer
  GMT (± SD) P GMT (± SD) P
NA/COS-7 34 (± 8) 0.36 160 (± 78) 0.01
NA/E. coli 13 (± 5)   60 (± 21)  
HA/COS-7 91.8 (± 35.7) 0.01 422 (± 175) 0.28
HA/E. coli 22 (± 8)   160 (± 87)  
NS1/COS-7 139* (± 35) 0.01 1688* (± 701) 0.01
NS1/E. coli 22 (± 8)   422 (± 175)  
M/COS-7 0 NA 40 (± 21) 0.1
M/E. coli 0   22 (± 8)  
  1. *Significant (P < 0.05, Mann-Whitney method, NS/COS-7 and other proteins)