Skip to main content

Table 1 Robust serum antibody response to simultaneous intradermal vaccination

From: An alternative approach to combination vaccines: intradermal administration of isolated components for control of anthrax, botulism, plague and staphylococcal toxic shock

    

Antibody concentration (μg/ml) mean ± SD

    

Vaccine

Isotype

Day

Treatment

 

BoNT/A(H c)

rF1-V

rPA

STEBVax

IgM

70

Control

(n = 8)

3.07+/-0.87

2.99+/-1.47

6.31+/-3.16

4.76+/-3.62

 

70

Vaccinated

(n = 24)

5.47+/-2.20

11.2+/-4.04

13.7+/-9.28

9.07+/-2.74

  

p-value*

 

0.0001

< 0.0001

0.002

0.012

IgG

14

Control

(n = 8)

0.31+/-0.15

2.1+/-3.1

0.31+/-0.12

1.25+/-1.76

 

14

Vaccinated

(n = 24)

1.4+/-1.1

421+/-196

86+/-46

121+/-109

  

p-value

 

< 0.0001

< 0.0001

< 0.0001

< 0.0001

 

42

Control

(n = 8)

0.28+/-0.22

1.95+/-0.98

2.2+/-1.4

1.23+/-0.91

 

42

Vaccinated

(n = 24)

4+/-2.1

767+/-382

689+/-397

323+/-187

  

p-value

 

< 0.0001

< 0.0001

< 0.0001

< 0.0001

 

70

Control

(n = 8)

0.65+/-0.37

1.05+/-1.08

0.91+/-0.44

1.93+/-1.25

 

70

Vaccinated

(n = 24)

48+/-13

2331+/-303

2245+/-1224

1340+/-215

  

p-value

 

< 0.0001

< 0.0001

< 0.0001

< 0.0001

  1. *Significance of mean serum IgM and IgG concentrations for control and vaccinated animals were compared using Student's t-test.