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Table 1 Robust serum antibody response to simultaneous intradermal vaccination

From: An alternative approach to combination vaccines: intradermal administration of isolated components for control of anthrax, botulism, plague and staphylococcal toxic shock

     Antibody concentration (μg/ml) mean ± SD
     Vaccine
Isotype Day Treatment   BoNT/A(H c) rF1-V rPA STEBVax
IgM 70 Control (n = 8) 3.07+/-0.87 2.99+/-1.47 6.31+/-3.16 4.76+/-3.62
  70 Vaccinated (n = 24) 5.47+/-2.20 11.2+/-4.04 13.7+/-9.28 9.07+/-2.74
   p-value*   0.0001 < 0.0001 0.002 0.012
IgG 14 Control (n = 8) 0.31+/-0.15 2.1+/-3.1 0.31+/-0.12 1.25+/-1.76
  14 Vaccinated (n = 24) 1.4+/-1.1 421+/-196 86+/-46 121+/-109
   p-value   < 0.0001 < 0.0001 < 0.0001 < 0.0001
  42 Control (n = 8) 0.28+/-0.22 1.95+/-0.98 2.2+/-1.4 1.23+/-0.91
  42 Vaccinated (n = 24) 4+/-2.1 767+/-382 689+/-397 323+/-187
   p-value   < 0.0001 < 0.0001 < 0.0001 < 0.0001
  70 Control (n = 8) 0.65+/-0.37 1.05+/-1.08 0.91+/-0.44 1.93+/-1.25
  70 Vaccinated (n = 24) 48+/-13 2331+/-303 2245+/-1224 1340+/-215
   p-value   < 0.0001 < 0.0001 < 0.0001 < 0.0001
  1. *Significance of mean serum IgM and IgG concentrations for control and vaccinated animals were compared using Student's t-test.
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