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Table 2 Simultaneous intradermal vaccination with four independent vaccines protected Rhesus macaques from fatal infectious or toxin-mediated disease

From: An alternative approach to combination vaccines: intradermal administration of isolated components for control of anthrax, botulism, plague and staphylococcal toxic shock

  Bot/A Challenge* Spore Challenge SEB Challenge
  Dose (LD50s) Survival** Dose (LD50s) Survival Dose (LD50s) Survival
Control 1 57 - 507 - 33.5 -
Control 2 100 - 412 - 18.0 -
Vaccinated 1 50 + 257 + 26.4 +
Vaccinated 2 24 + 487 + 25.6 +
Vaccinated 3 99 + 439 + 15.8 +
Vaccinated 4 43 + 373 + 18.9 +
Vaccinated 5 82 + 275 + 19.6 +
Vaccinated 6 62 + 263 + 23.4 +
Mean+/-SD 65+/-27   377+/-101   23+/-6  
  1. *All disease challenges occurred one month after the final vaccination.
  2. **Efficacy was evaluated using Fishers exact test comparing the treated group to the control group for each agent consisting of 2 experimental controls and 15 historical controls. Results indicated that the percentage of animals surviving in each treatment group (6/6 or 100%) was significantly higher than the percentage of animals surviving in each pooled (experimental plus historical) control group (0/17 or 0%), p < 0.0001.
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