Figure 2

Dose assessment for chimaeric VLP boost. Three groups of five BALB/c mice were primed on day 0 with the DNA vaccine pVRCgrttnC and boosted with (a) GagRT or (b) GagTN on day 28. For all mouse groups spleens were harvested on day 40 and the splenocytes were used in IFN-γ ELISPOT and IL-2 ELISPOT assays with the indicated Gag and RT CD8 and CD4 peptides. Data represent results from one of three representative experiments.